Manual of the Diagnosis of Rinderpest. (FAO Animal Health Manual - 1)













Table of Contents


SECOND EDITION

J. Anderson and T. Barrett
Institute for Animal Health Pirbright, United Kingdom

G.R. Scott
Centre for Tropical Veterinary Medicine University of Edinburgh
Edinburgh, United Kingdom

FOOD AND AGRICULTURE ORGANIZATION OF THE UNITED NATIONS
Rome, 1996

The designations employed and the presentation of material in this publication do not imply the expression of any opinion whatsoever on the part of the Food and Agriculture Organization of the United Nations concerning the legal status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries.

M-27
ISBN 92-5-103814-7

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© FAO 1996

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Table of Contents


Preface

Preface to first edition

Abbreviations

PART I - THE PRESUMPTIVE DIAGNOSIS

Chapter 1. Epizootiological background

The causative virus
Natural host range
Transmission

Chapter 2. Clinical signs

Buffalo and cattle infections
Goat and sheep infections
Domestic pig infections

Chapter 3. Clinical pathology

Haematological changes
Biochemical changes

Chapter 4. Post-mortem findings

Buffalo and cattle deaths
Goat and sheep deaths
Pig deaths

PART II - DIAGNOSTIC SPECIMENS

Chapter 5. Collection of specimens

Donor selection
Biopsies
Post-mortem specimens
Recommended procedure

Chapter 6. Shipment of specimens

National movements
International movements
Receipt of specimens

PART III - CONFIRMATORY DIAGNOSIS

Chapter 7. Antigen detection

Agar-gel immunodiffusion (AGID)
Counterimmunoelectrophoresis (CIEP)
Passive haemagglutination (PHA)
Immunofluorescence (IF)
Immunoperoxidase staining (IPS)
Immunocapture ELISA
Electron microscopy (EM)
Polymerase chain reaction (PCR)

Chapter 8. Antibody detection

Development of antibodies
Diagnostic role of antibody detection
Virus neutralization
Enzyme-linked immunosorbent assay (ELISA)

Chapter 9. Virus isolation and identification

Isolation in cell cultures
Virus identification
Isolation in buffaloes and cattle

Chapter 10. Histopathology and immunohistology

Histopathology
Immunohistology

Chapter 11. Differential diagnosis

Peste des petits ruminants (PPR)
Bovine virus diarrhoea (BVD)
Mucosal disease
Malignant catarrhal fever (MCF)
Bluetongue
Foot-and-mouth disease (FMD)

PART IV - APPENDIXES

Appendix 1. Preparation of hyperimmune anti-rinderpest serum in rabbits
Appendix 2. Stock solutions
Appendix 3. Fifty percent effective dose (ED50): Spearman-Kärber method
Appendix 4. Formulae for calculating Tm and oligonucleotide concentration
Bibliography