Parasite antigens - Summary proceedings of an international work-shop













Table of Contents


Held in Nairobi, Kenya
13-17 May 1985

INTERNATIONAL LABORATORY FOR RESEARCH ON ANIMAL DISEASES

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Table of Contents


Foreword

Opening address

Approaches to identification and characterization of potentially protective antigens - Chairperson: C. Jacob

Use of monoclonal antibodies to detect antigens of malaria parasites
Use of infection sera to detect antigens of malaria parasites
Identification of protective antigens of Anaplasma organisms

Approaches to identification and characterization of potentially protective antigens - Chairperson: G.V. Brown

Antigens of sporozoites of Theileria parva
Cell-mediated immunity as a tool for identification of protective antigens (Theileria parva)
Protective antigens of' African Trypanosomes

Identification and expression of antigen genes

In vitro peptide synthesis
Expression vectors
Construction of a genomic library
Progress in malaria
Progress in Anaplasmosis
Progress in theileriosis: 1. Construction of Theileria parva genomic libraries and identification of sporozoite and macroschizont-specific genes
Progress in Theileriosis: 2. Identification of genes encoding important protective antigens of sporozoites of Theileria parva

Induction of protective responses

Synthetic approaches to vaccine development against cholera-like heat-labile proteins
The role of synthetic adjuvants for enhancement of vaccines

New approaches to diagnosis of parasitic diseases

Use of monoclonal antibodies and DNA probes for diagnosis of parasitic diseases
Development of monoclonal antibodies and specific antigens for diagnosis of African trypanosomiasis
Development of DNA probes for identification of African trypanosomes
Development of nonradioactive DNA probes for identification of African trypanosomes
Genotype analysis of trypanosomes
Use of monoclonal antibodies and DNA probes for theilerial strain/species characterization

Conclusions and recommendations

Selected references provided by speakers

Participants