Research Group

2006 Session of the Research Group of the Standing Technical Committee of EuFMD

Paphos, Cyprus

17-20 October 2006

INTERNATIONAL CONTROL OF FOOT-AND-MOUTH DISEASE: TOOLS, TRENDS AND PERSPECTIVES
FULL report
Agenda
List of participants
Thematic Areas Papers presented at the meeting on thematic area
FMD Control Lessons and issues arising from recent FMD control experience in the region The impact of farm gate biosecurity on the transmission of FMD in UK in 2001 Spatially fragmented and non-fragmented disease clusters in FMD epidemics Risk Analysis A global model for prediction of FMD risk Fraud in trade in agricultural products related to public and animal health risks Active surveillance for FMDV in Bulgaria and Risk Assessment for the penetration of the disease between the years 2004-2006 FMD risk of importation: where to control? Contingency planning and simulation exercises Inventory of web accessible recent FMD Real-time Alert Exercises carried out by European and other Countries The Animal Health Quadrilateral Epiteam – International collaboration on Foot-and-Mouth Disease simulation modelling for emergency preparedness Combining the use of epidemiological and economic models as an aid in preparing contingency plans: a New Zealand case study A climatological atlas of the risk of airborne spread of FMD in New Zealand Epidemiology Global Update of Foot-and-Mouth Disease (2004-2006) Recent molecular epidemiology of foot-and-mouth disease virus Asia 1 Recent spread of new strains of foot-and-mouth disease virus type A in the Middle East and North Africa Preliminary findings from a new project on the epidemiology of FMDV in Pakistan A study on foot and mouth disease (FMD) virus serotypes circulating in Ethiopia Foot-and-Mouth disease serotypes SAT1 and SAT2 Epidemiology in East Africa A serological survey for foot-and-mouth disease in wildlife in East Africa UC Davis FMD models for spatial distribution, sampling, and virus evolution Genetic tracing of foot-and-mouth disease virus during the UK 2001 outbreak Characterization, including VP1 and full-length sequencing of type A and O strains collected from Foot-and-Mouth disease outbreaks since 1996 in Turkey Virus Transmission Susceptibility of North American wild ungulates to foot-and-mouth disease virus: initial findings Dromedaries (Camelus dromedarius) are of very low susceptibility to experimental, highdose inoculation with FMDV Serotype O and do not transmit the infection to direct contact camels or sheep Understanding FMDV transmission between cattle – preliminary data from animal experiments Difference in virus excretion and transmission between dairy cows and calves in the course of an acute FMDV infection Airborne spread of Foot-and-Mouth Disease Vaccine development, vaccine production and (strain) selection Dissecting Immune Responses Use of monoclonal antibodies for the selection of Foot-and-Mouth Disease (FMD) vaccine Preliminary results to evaluate cross-protection between O1 Manisa and O1 Campos in cattle Cedivac-FMD; Duration of Immunity in cattle, sheep and pigs Vaccine control, validation and quality control European Pharmacopoeia foot-and-mouth disease vaccine potency test: between test variability European Pharmacopoeia potency test for FMD vaccine: The influence method of potency trial, serotype, type of adjuvant, valency and virus culture on dose-response curve Importance of cell mediated immunity for protection against Foot and Mouth Disease A novel proteomics-based approach for the characterization of FMDV antigens Vaccine application Comparison of FMDV type O, A and Asia 1 antibody levels after vaccination of cattle, sheep, dromedary camels and horses Cedivac-FMD, a marker vaccine? Further evaluation of higher potency vaccines for protection from FMDV direct contact challenge Quantification of foot and mouth disease virus excretion and transmission within groups of sheep with and without vaccination Emergency vaccination against FMD in pigs: influence of used vaccine dose and correlation between induced immunological responses and reduction of virus shedding Foot and mouth disease immunoprophylaxis using single-domain antibody fragments Dendrimeric Peptide containing Foot-and-Mouth disease virus (FMDV) specific B- and T-Cell Epitopes, Confer full protection to pigs against challenge with FMDV RECOMMENDATIONS concerning Vaccine application Diagnostics: detection and typing of infection Use of monoclonal antibodies to identify and map new antigenic determinants involved in neutralisation on FMD viruses type SAT 1 and SAT 2 Foot and Mouth Disease Serum Neutralization response versus needle virus challenge results in free range buffaloes Diagnosis of FMD by RT-PCR: prospects for mobile and portable assays Preliminary study of the use of thermal imaging to assess surface temperatures during foot-and-mouth disease virus infection in cattle, sheep and pigs Rapid, simple, field-deployable FMDV detection RECOMMENDATIONS concerning Vaccine application Diagnostics: DIVA tests Bovine serum panel for evaluation of FMDV non structural protein antibody tests Foot-and-mouth disease non-structural protein serology: use of a Bayesian framework to estimate sensitivity and specificity of six ELISA tests and disease prevalence in the field Comparison of ELISAs for antibodies against foot-and-mouth disease virus non-structural proteins in cattle sera based on the continuous results Comparative evaluation of serological tests for the detection of foot-and-mouth disease virus infection in vaccinated pigs Evaluation of Emergency FMD vaccine in pigs following direct contact challenge Establishment and validation of a 3ABC indirect ELISA for differentiation of foot-and-mouth disease virus infected and vaccinated animals 3D ELISAs as potential confirmatory principle in DIVA and type-independent assay for FMDV antibodies Detection of FMD antidodies by a 3D-ELISA Diagnostics: confidence in results FAO Collaborative Studies for FMD Standardisation: Phase XIX - Virological Assays FAO Phase XIX FMD Inter-laboratory Comparative Test Exercise on Serology Measurement of uncertainty for Elisa Tests Pathogenesis: Virus Host interaction Quantitative analysis of cytokine mRNA induction in micro-dissected epithelium in cattle during foot-and-mouth disease virus infection Foot-and-mouth disease virus causes transplacental infection and death in foetal lambs Positive RT-PCR test results in tonsils of foot and mouth disease virus infected piglets after more than 28 days An amino acid change in the B-C loop of VP2 associated with persistent FMDV infection in experimentally infected cattle 2’-C-Methylcytidine, a potent and selective inhibitor of the replication of the foot-and-mouth disease virus The inhibition of FMD virus excretion from the infected pigs by an antiviral agent, T-1105
Appendixes to Closed Session Report
Appendix 65
Appendix 66