Research Group

2008 Open Session of the EuFMD Standing Technical Committee

Erice, Sicily

14-16 October 2008 (Open Session)

17 October 2008 (Closed Session)

The Global Control of FMD
Tools, Ideas and Ideals

AGENDA - OPEN SESSION

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AGENDA - POSTER SESSION

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List of participants

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Dr. Gaetana Ferri full address

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REPORT OF THE OPEN SESSION

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Reccomendations

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Appendixes / Presentations

Session 1:
Global FMD control through regional co-ordinated actions: opportunities and constraints

4. Keynote FAO/OIE representative: Global FMD control: opportunities and constraints

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5. Global FMDV distribution and regional virus reservoirs: an opportunity to divide and control?

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6. Hemispheric Program for the Eradication of FMD (PHEFA) Successes and Challenges

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7. FMD Type C situation – The first target for eradication

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8. Progress in FMD control in Iran: and perspective on longer term control in the region

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9. Phylogenetic study of FMDV isolates collected in Russia, CIs-countries and Mongolia in 2000-2007

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10. Constraints and opportunities for the control of foot and mouth disease in India

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11. The global FMD research alliance (GFRA)-an R&D response to the major constraints to global FMD control

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Vaccination - 2A:
Optimizing programs in a situation of limited resources

12. Keynote: Vaccination: Overcoming the constraints to achieving effective immunity rates

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13. Intradermal vaccination with 1/10 dose against FMDV protects pigs as well against clinical disease and subclinical virus shedding as intramuscolar vaccination with a full dose

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14. Foot-and-mouth disease (FMD) vaccination strategies in sheep and lambs by using commercial oil vaccine

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15. Longevity of protection in cattle following vaccination with emergency FMD from the UK strategic reserve – Preliminary results

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Vaccination - 2B:
Overcoming antigenic diversity in simplifying preventive programs

16. High potency vaccines induce protection against heterologous challenge with foot-and-mouth disease virus

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17. Predicting antigenic sites on the FMDV capsid from cross-reactivity data

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18. Vaccine matching: reliability of foot-and-mouth disease (FMD) r-values determination

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19. Towards vaccine selection guidelines for each regional virus pool of foot-and-mouth disease

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Session 2C:
Novel vaccine delivery approaches: progress updates

20. Expression of FMDV capsid proteins in silkworm-baculovirus expression system and its utilization as an empty Capsid vaccine

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21. Potential of modified vaccinia Ankara (MOA) as a vaccine delivery vector for foot-and-mouth disease virus (FMDV)

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22. Marker potential of a vaccine prepared from a foot-and-mouth disease virus with a partial vp1 g-h loop Deletion

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23. Frenkel lecture: FMD vaccine development - past and future

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Session 2D:
FMD vaccine standards required for global control

24. Keynote: Vaccine quality tests, the value of alternative methods?

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25. A standardized direct contact challenge method for FMDV in swine

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26. Can in vitro methods reliably replace existing vaccine challenge tests?

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27. Correlating vaccine induced protection with humoral and cellular immune responses to FMDV: potential in vitro assays for replacement of potency test

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28. Development of a foot-and-mouth disease vaccine potency test without conducting animal challenge experiment

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Session 3:
Biosecurity and buy-in

29. Keynote: Biosecurity, what’s in it for me?

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30. Foot-and-mouth disease control in endemic settings: combining epidemiology, risk assessment and value chains analysis to identify risk control points

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31. Bridging the divide between two bona fide guardians of society’s interests: the disease exterminators and the Sustainable growth advocates

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32. Keynote: global surveillance for fmd – what are we doing and what could be done

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Session 4:
Measure progress in global and regional FMD control, and early warning of FMDV emergence

33. Keynote: Global surveillance of foot-and-mouth disease: concepts, considerations, and requirements

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34. Sampling, shipping, organisation and testing of inactivated samples to take advantage of molecular analysis Methods

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35. Use of infrared thermography to detect signs of foot–and-mouth disease in wild and domestic ungulates

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36. Sequence identification and genetic profile of FMDV in a 2007 disease outbreak in Israel using full length Genomic analysis

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37. Identification of virulence determinants in FMDV: potential use of functional genomics to predicting viral Pathotypes

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38. The distribution of NSP positive animals in regular vaccinated herds as criterion for effectiveness of vaccine And vaccination during endemic year

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39. Estimating the vaccination coverage in an FMD free zone-brazil 2005/2006

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40. Management of sat-type FMD in southern Africa: present control and trade standards are inappropriate

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Session 5:
Diagnostics: making quality services available where need

41. Keynote diagnostics: a new era in access to high performance diagnostics

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42. Fmd and SVD combined proficiency test studies 2008 – Virological assays

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43. FMD and SVD combined proficiency test scheme studies 2008 (phase xxi) – Serology

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44. Keynote: Driving up global standards for FMD diagnostic, a key role for proficiency testing and international organisations

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45. An advanced field deployable “pen side” sample preparation and PCR system

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46. Validation of real-time RT-PCR: matrix effect, uncertainty of measurement and precision

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47. Development of solid phase competitive ELISAs based on monoclonal antibodies for the serology of FMDV. Serotypes sat1 and sat2

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48. Full genome sequencing to support tracing of UK outbreaks of FMD

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49. Sero-surveillance against foot-and-mouth disease virus (FMDV) non-structural protein antibodies in sheep, Goats and cattle in Jordan after 2006 outbreak

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Parallel Session 5:
Epidemiology

50. Anticipatory control measures: geographical information systems-based identification of topographic factors Acting as obstacles or disseminators in the 2001 Uruguayan FMD epidemics

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51. Network analysis of livestock movements to estimate potential silent spread of foot-and-mouth disease

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52. Modelling of FMD outbreaks in The Netherlands: vaccination and regaining the status ‘freedom of infection

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53. Defining the period of infectiousness in cattle naturally infected with foot-and-mouth disease virus

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54. UK 2001 foot-and-mouth disease epidemic: sequence data and possible airborne spread

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55. Localisation of foot-and-mouth disease virus after acute infection in cattle; a novel, immunologically significant site

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56. Investigations into findings of FMD seropositive sheep and goats in Cyprus, an FMD-free country

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57. Results of molecular testing of samples from Pakistan

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58. Tracing 2007-2008 emergency episodes of foot-and-mouth disease virus in south America: phylogenetic Analysis

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59. Sero-prevalence of foot-and-mouth disease in small ruminants under contrasting husbandry practices in Uganda

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60. The status of foot-and-mouth disease (FMD) in Ethiopia

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Session 6:
Components and capacity for effective control

61. Factors influencing global FMD reporting and risk

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62. Participatory epidemiology as compared to conventional foot and mouth disease surveillance tool

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63. Development of an improved capability in support of national bio-security for the surveillance and control of Foot-and-mouth disease in cattle and pigs in Viet Nam

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Parallel Session 6: Diagnostics

64. Detection of FMDV serotypes o, a and Asia 1 by real-time RT-PCR

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65. Linear-after-the-exponential (late) PCR: new detection technologies for pan-FMDV and serotype-specific assays In the field

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66. Evaluation of a lateral flow device for the pen-side diagnosis of foot-and-mouth disease

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67. Detection of persistently foot-and-mouth disease infected cattle by salivary IGA test

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68. Development and evaluation of IGM ELISA for the detection of FMDV specific IGM antibodies in bovine and ovine sera

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Session 7:
Prospects for integrating anti-viral approaches

69. Enhanced prospects for FMDV anti-virals targeted to the 3c protease

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70. An antiviral agent, t-1105 prevents from virus excretion from pigs infected with porcinophilic foot-and-mouth Disease virus

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Session 8:
Strategy for regional and global control

71. Elements of a global strategy

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Poster Session

72. A foetal goat tongue cell line found highly sensitive for foot-and-mouth disease virus

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73. Epizootiological study of foot-and-mouth disease in the Sudan

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74. Status of foot-and-mouth disease in Pakistan

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75. The relation antibody and protection after foot-and-mouth disease vaccination cannot be standardised

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76. Study of immnunobiologic characteristics

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77. Piglets with maternally derived antibodies can be vaccinated at 2 weeks of age

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78. In vivo and in vitro tests to detect non-structural proteins in foot and mouth disease vaccines

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79. Targeting FMDV minigenes to SLA ii positive cells enhances the induction of cellular responses in swine and Confers protection against viral challenge

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80. Control of foot and mouth disease under public-private partnership (PPP)

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Closed Session

81. List of participants

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82. Provisional agenda - standing technical committee of the eufmd commission

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83. Item 2: Minimum containment standards for FMD laboratories

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84. Item2.1: Minimum standards of biorisk management for laboratories undertaking diagnostic investigations of low-risk samples during an outbreak of FMD

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85. Item 3 proposed minimum requirements for adoption at the 38th eufmd general session (2009) as a minimum for member states

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86. Options for decentralised diagnosis of secondary cases of foot-and-mouth disease in any future outbreak

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87. Transport of FMDV RNA rather than live virus; optimisation of viral recovery by transfection of infectious RNA

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88. Item 6. Sero-surveillance in Turkey: the question of harmonising the performance/interpretation of sp antibody Data with/between RG member laboratories

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POSTERS

Diagnostics

Foetal goat tongue cell line is highly sensitive for foot-and-mouth disease virus

Validation of solid phase epitope blocking ELISA (SPEBE) (...)

Evaluation of profiling ELISA for antibodies to NSP of FMD

Preliminary evaluation of panels of monoclonal antibodies developed against 4 vaccine strains (...) 

Baculovirus expression of NSP 3D of FMDV and its use as antigen in ELISA for differentiation of infected from vaccinated animals     

Diagnostic strategy for FMDV - the Bulgarian approach

Mapping of linear antigenic sites of the NSP 3D of FMD relevant for the recognition of an infection status

Epidemiology

Epizootiological study of FMD in Sudan (The situation after two decades) 

Status of foot-and-mouth disease in Pakistan

Global Control

Novel Funding Sources for Hemispheric Improvement of FMD preparedness and response: Project scope & Progress to date 

Inter-American group for the eradication of foot-and-mouth disease (GIEFA)

Other

Effective inhibition of foot-and-mouth disease virus by multiple short hairpin RNAS expression in A adenovirus 

 An in-vitro cell culture model, investigating infection of novel cell types with foot-and-mouth disease 

Development of a cell line stably expressing T7 RNA polymerase using retroviral gene transfer technology (...) 

Infectious bursal disease subviral particles displaying the foot-and-mouth disease virus major antigen

Immunity, Vaccines and Vaccination

The relation antibody and protection after Foot-and-Mouth Disease vaccination cannot be standardised 

Impact of cytokine response on FMDV infection outcome in cattle

Measurement of FMDV antigen stability using single domain antibody fragments

Understanding FMDV transmission between vaccinated cattle – preliminary data from animal experiment 

A quantitative assessment of primary and secondary immune responses in cattle using the B cell ELISPOT assay 

Piglets with maternally derived antibodies can be vaccinated at 2 weeks of age

Quantification of transmission of FMDV strain Asia-1 Turkey among vaccinated and non-vaccinated lambs 

Cliptox increased the protection levels induced by an FMDV inactivated vaccine

Targeting FMDV minigenes to SLA II positive cells enhances the induction of cellular responses (...) 

CD4+ T cell Responses to foot-and-mouth disease virus (FMDV) in vaccinated Cattle.

Development of a fast release immunomodulated vaccine against FMD virus. Induced immunity