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AVIAN INFLUENZA
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Avian influenza at the human-animal interface


FAO-OIE-WHO Joint Technical Consultation

Verona, Italy, 7-9 October 2008
Presentations from the technical consultation called by the Food and Agriculture Organization of the United Nations (FAO), the World Organisation for Animal Health (OIE) and the World Health Organization (WHO), with support from the Istituto Zooprofilattico Sperimentale delle Venezie (IZSVe) and the EC-funded FLUTRAIN project, to:

identify critical virological characteristics for the emergence of zoonotic and pandemic viruses
evaluate external factors affecting the evolution and emergence of a pandemic strain, and identify monitoring mechanisms for pandemic strain emergence
identify likely modes of transmission and exposure sources for zoonotic infection with avian influenza viruses
maximise outcome of ongoing research and preparedness efforts, and identify gaps in knowledge
identify next steps for further integrated data collection, analysis and research
SPECIAL ISSUE: FAO-OIE-WHO Joint Technical Consultation on Avian Influenza at the Human-Animal Interface. 7 - 9 October, 2008; Verona, Italy; Consultation Summary, May 2010


INTRODUCTION

Ilaria Capua
Objectives, Methods and Outcome



SESSION 1
VIROLOGICAL CHARACTERISTICS OF INFLUENZA VIRUSES

Sylvie Briand
Overview of human cases of AI H5N1 since 1997

Ian Brown
Overview of animal outbreaks of AI H5N1 globally since 1997

Ilaria Capua (and Denis Alexander)
Circulation of other avian influenza viruses with zoonotic potential

Mike Perdue
Advanced Development, Stockpiling and Infrastructure/Capacity Building ľ Countermeasures to Prevent Avian Influenza

Giovanni Cattoli
Occurrence of avian H5N1 strains isolated in Africa and in the Middle East (2006-2008) of mutations with potential human health implications

Ron Fouchier
Influenza virus infectivity, pathogenicity and transmissibility in humans

Mikhail Matrosovich
Receptor specificity and host range

Masato Tashiro
Specific characteristics of interest for public health

Kristien Van Reeth
Zoonotic potential of non-avian influenza A viruses



SESSION 2
EVOLUTION AND EMERGENCE OF A PANDEMIC STRAIN

Ruben Donis
Viral characteristics of H5N1 influencing mutation/reassortment events with pandemic potential

Ab Osterhaus
External factors influencing H5N1 mutation/reassortment events with pandemic potential

Gavin Smith (and Yi Guan)
Evolution of H5N1 in birds

Richard Webby
Evolution of human pandemic viruses

Gwenaelle Dauphin
OFFLU activities at the Human-Animal interface

Alan Hay
WHO Process for Monitoring Novel Influenza Viruses

Derek Smith
The role of antigenic cartography in monitoring



SESSION 3
HUMAN TRANSMISSION RISKS & EXPOSURE SOURCES

Allison McGeer
Models of Transmission of Seasonal Human Influenza Viruses

David Swayne (and Jackie Katz & Terry Tumpey)
Possible Modes of Transmission of Avian Viruses to People: Studies in Experimental Models

Peter Horby
Why are so few people getting infected in face of large exposed population?

Wantanee Kalpravidh
Cultural Practices and Risk of HPAI Infection in Humans

Liz Mumford (and Mike Arget)
WHO data on potential sources of human exposure to avian influenza H5N1

Malik Peiris
Potential role of live animal markets and the environment in human exposure to avian influenza viruses

Gina Samaan
Live Bird Markets: keeping them alive?

Les Sims
Effects of poultry management on risk of human exposure (at the community level)

David Swayne (and A. Lipatov, Y.K. Kwon, M. Jackwood & J. Beck)
Potential Role of Exposure to Poultry Products and By-products for Human H5N1 Infections

Mona Aly
Summary of animal health information relevant to human exposure to HPAI H5N1 in Egypt

Mona Aly
Summary of exposure data in Egyptian human cases
Presentation not available

Hualan Chen (presented by Vincent Martin)
Summary of animal health information relevant to human exposure to avian influenza H5N1 in China

Zhou Lei
Summary of exposure data in Chinese human cases of H5N1
Presentation not available

Wilfried Purba
Summary of exposure data for human cases of H5N1 in Indonesia

Elly Sawitri
Summary of animal health information relevant to human exposure to avian influenza H5N1 in Indonesia

Nguyen Tran Hien
Avian Influenza in Viet Nam: Situation and Lessons Learned

Nguyen Tung
Summary of animal health information relevant to human exposure to avian influenza H5N1 in Viet Nam



SESSION 4
DEVELOPMENT OF MEETING OUTPUT

No presentations



SESSION 5
BROADENING THE USE OF TOOLS AND SYSTEMS

Pierre Formenty
Tools and methods used to evaluate emergence of other zoonotic diseases

Lonnie King
The Importance of the H-A Interface in the Broader Sense

Juan Lubroth
The Global Early Warning System for transboundary animal diseases including major zoonoses (GLEWS)



CONCLUSION

Conclusions, Gaps and Proposed Actions