Rift Valley fever (RVF) is an acute arthropod-borne infection first recognized in Kenya in 1931. Today, the RVF virus has been found in countries across Africa, the Arabian Peninsula and islands in the Indian Ocean, including Madagascar, Comores and Mayotte. This virus has a strong capacity to spread to previously unaffected areas, thanks to its broad host range and ability to be transmitted by at least 30 different mosquito species ¿some of which are found in Europe, Australasia and the Americas. Outbreaks following first incursions of RVF can result in explosive epidemics involving both humans and livestock.

The control of RVF outbreaks includes vaccination of susceptible animals. Two vaccines are currently available; however, each has significant drawbacks. There is a widely recognized need to develop safer and more efficacious vaccines for animals. Rift Valley fever vaccine development, progress and constraints is the report of an international expert workshop that brought together leading experts and policy-makers in RVF virology, epidemiology and vaccine development. The workshop objective was to gain consensus and make recommendations on the desired features of novel veterinary RVF virus vaccines, and to explore how incentives can be established to assure that these vaccines come to market.

Table of contents





List of acronyms
Abstract


Past and present control of RVFV: What is needed

View from international organizations and industry

OIE activities and standards related to RVF
View from the European Commission
View from the USDA
View from GALVmed
View of the Animal Health Industr

Efficacy and safety of novel candidate vaccines

The MP-12 virus
The Clone-13 virus
RVFV lacking the NSs and NSm genes and DIVA
Capripox viruses as vaccine vectors
An avian paramyxovirus as a vaccine vector
DNA vaccines and their combination with Modified Vaccinia Ankara vectors
DNA vaccines and their combination with Alphavirus replicon vectors
Virus-like particles as RVFV vaccines
Transcriptionally-active VLPs as RVFV vaccines

Summary discussion

Which vaccine for where?
The need for robust animal models
A human RVF vaccine: all it needs is a “pull”

Recommendations

References

List of participants

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ISBN 978-92-5-106921-9

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