Given the global relevance of Integrated Food-Energy Systems (IFES), FAO has developed the IFES Analytical Framework; which gives guidance on how to select and assess indicators of IFES sustainability. The Analytical Framework (AF) includes a set of criteria, indicators and measures to help screen IFES projects. The first part of the AF screens IFES projects based on their environmental, social and economic sustainability. The second part of the AF contains a set of leading questions and related features that will help to analyse which factors make IFES replicable. In order to upscale sustainable biomass production, it is important to understand the drivers and the barriers that encourage or limit the long-term adoption of sustainable biomass production practices such as IFES. The question at stake is: Can an IFES that has been proven to be sustainable in one location or community, be taken up in other locations, by other communities, be it in the same region, country or even abroad? One needs to recognize that there are large differences between different IFES, on the one hand, and different geographical and cultural areas where the replication might take place, on the other. Yet we argue that there are some common denominators or features that lie within the project and that create an enabling environment for the uptake of a specific IFES project. These features need to be built into and adapted to the specific context of an IFES when replicated elsewhere.