Tsetse-transmitted trypanosomosis is a lethal parasitic disease of humans and livestock. The disease severely limits mixed livestock–crop agriculture in over 10 million km2 of highly productive land in sub-Saharan Africa. Direct and indirect losses due to trypanosomosis are estimated in billions of dollars every year. The disease is often neglected by both endemic countries and donors as it mostly affects poor and vulnerable small-holders in rural areas.