APPENDIX II: DRAFT MAXIMUM RESIDUE LIMITS FOR VETERINARY DRUGS ADVANCED TO STEP

alpha-Cypermethrin

ADI:	0-20 µg/kg body weight (1996)
Residue Definition:	alpha-Cypermethrin

Species	Tissue	MRL	(µg/kg)	Step	JECFA	CCRVDF
cattle	muscle	100	T	8	47	10V
sheep	muscle	100	T	8	47	10V
chicken	muscle	100	T	8	47	10V
cattle	liver	100	T	8	47	10V
sheep	liver	100	T	8	47	10V
chicken	liver	100	T	8	47	10V
cattle	kidney	100	T	8	47	10V
sheep	kidney	100	T	8	47	10V
chicken	kidney	100	T	8	47	10V
cattle	fat	500	T	8	47	10V
sheep	fat	500	T	8	47	10V
chicken	fat	500	T	8	47	10V
cattle	milk	25	(µg/l) T	8	47	10V
chicken	eggs	50	T	8	47	10V

Azaperone

ADI:	0-6 µg/kg body weight (1998)
Residue Definition:	Sum of azaperone and azaperol

Species	Tissue	MRL	(µg/kg)	Step	JECFA	CCRVDF
pig	muscle	60		8	38, 43, 50	9V, 10V
pig	liver	100		8	38, 43, 50	9V, 10V
pig	kidney	100		8	38, 43, 50	9V, 10V
pig	fat	60		8	38, 43, 50	9V, 10V

Keys for List of MRLs for Veterinary Drugs

ADI	Acceptable Daily Intake (expressed in micrograms/kilogram body weight)
Tissue	Muscle, Liver, Kidney, Fat, Fat/Skin, Milk or Egg
MRL	Maximum Residue Limit (unless noted otherwise, expressed in micrograms/kilogram)
Step	Step of the MRL at the time of consideration by the CCRVDF or Year of its adoption by the Codex Alimentarius Commission
JECFA	Meeting number of the Joint FAO/WHO Expert Committee on Food Additives where the substance was evaluated and/or MRL recommended/considered
CCRVDF	Session number of the CCRVDF where the MRL was considered and Appendix number of its report where the MRL is contained.

Bovine somatotropins

ADI:	Not specified (1992) The ADI applies to somagrebove, sometribove, somavubove, somidobove.
Residue Definition:	Not applicable

Species	Tissue	MRL	(µg/kg)		Step	JECFA	CCRVDF
cattle	muscle	not specified		1/	8	40, 50	7IV, 8II
cattle	liver	not specified		1/	8	40, 50	7IV, 8II
cattle	kidney	not specified		1/	8	40, 50	7IV, 8II
cattle	fat	not specified		1/	8	40, 50	7IV, 8II
cattle	milk	not specified		1/	8	40, 50	7IV, 8II

ADI "not specified" means that available data on the toxicity and intake of the veterinary drug indicate a large margin of safety for consumption of residues in food when the drug is used according to good practice in the use of veterinary drugs. For that reason, and for the reasons stated in the individual evaluation, the JECFA concluded that use of the veterinary drugs does not represent a hazard to human and that there is no need to specify a numerical ADI.

1/ MRL "not specified" means that available data on the identity and concentration of residues of the veterinary drug in animal tissues indicate a wide margin of safety for consumption of residues in food when the drug is used according to good practice in the use of veterinary drugs. For that reason, and for the reasons stated in the individual evaluation, the JECFA concluded that the presence of drug residues in the named animal product does not present a health concern and that there is no need to specify a numerical MRL.

Ceftiofur

ADI:	0-50 µg/kg body weight (1995)
Residue Definition:	Desfuroylceftiofur

Species	Tissue	MRL	(µg/kg)	Step	JECFA	CCRVDF
cattle	muscle	1000		8	45, 48	9IV, 10III
pig	muscle	1000		8	45, 48	9IV, 10III
cattle	liver	2000		8	45, 48	9IV, 10III
pig	liver	2000		8	45, 48	9IV, 10III
cattle	kidney	6000		8	45, 48	9IV, 10III
pig	kidney	6000		8	45, 48	9IV, 10III
cattle	fat	2000		8	45, 48	9IV, 10III
pig	fat	2000		8	45, 48	9IV, 10III
cattle	milk	100	(µg/l)	8	45, 48	9IV, 10III

Cypermethrin

ADI:	0-50 µg/kg body weight (1996)
Residue Definition:	Cypermethrin

Species	Tissue	MRL	(µg/kg)	Step	JECFA	CCRVDF
cattle	muscle	200	T	8	47	10V
sheep	muscle	200	T	8	47	10V
chicken	muscle	200	T	8	47	10V
cattle	liver	200	T	8	47	10V
sheep	liver	200	T	8	47	10V
chicken	liver	200	T	8	47	10V
cattle	kidney	200	T	8	47	10V
sheep	kidney	200	T	8	47	10V
chicken	kidney	200	T	8	47	10V
cattle	fat	1000	T	8	47	10V
sheep	fat	1000	T	8	47	10V
chicken	fat	1000	T	8	47	10V
cattle	milk	50	(µg/l) T	8	47	10V
chicken	eggs	100	T	8	47	10V

Diclazuril

ADI:	0-30 µg/kg body weight (1998)
Residue Definition:	Diclazuril

Species	Tissue	MRL	(µg/kg)	Step	JECFA	CCRVDF
sheep	muscle	500		8	45, 50	9V, 10V
rabbit	muscle	500		8	45, 50	9V, 10V
poultry	muscle	500		8	45, 50	9V, 10V
sheep	liver	3000		8	45, 50	9V, 10V
rabbit	liver	3000		8	45, 50	9V, 10V
poultry	liver	3000		8	45, 50	9V, 10V
sheep	kidney	2000		8	45, 50	9V, 10V
rabbit	kidney	2000		8	45, 50	9V, 10V
poultry	kidney	2000		8	45, 50	9V, 10V
sheep	fat	1000		8	45, 50	9V, 10V
rabbit	fat	1000		8	45, 50	9V, 10V
poultry	fat/skin	1000		8	45, 50	9V, 10V

Dihydrostreptomycin/Streptomycin

ADI:	0-50 µg/kg body weight (1997) Group ADI for combined residues of dihydrostreptomycin and streptomycin.
Residue Definition:	Sum of dihydrostreptomycin and streptomycin

Species	Tissue	MRL	(µg/kg)	Step	JECFA	CCRVDF
cattle	muscle	500	T	8	43, 48	9V, 10V
pig	muscle	500	T	8	43, 48	9V, 10V
sheep	muscle	500	T	8	43, 48	9V, 10V
chicken	muscle	500	T	8	43, 48	9V, 10V
cattle	liver	500	T	8	43, 48	9V, 10V
pig	liver	500	T	8	43, 48	9V, 10V
sheep	liver	500	T	8	43, 48	9V, 10V
chicken	liver	500	T	8	43, 48	9V, 10V
cattle	kidney	1000	T	8	43, 48	9V, 10V
pig	kidney	1000	T	8	43, 48	9V, 10V
sheep	kidney	1000	T	8	43, 48	9V, 10V
chicken	kidney	1000	T	8	43, 48	9V, 10V
cattle	fat	500	T	8	43, 48	9V, 10V
pig	fat	500	T	8	43, 48	9V, 10V
sheep	fat	500	T	8	43, 48	9V, 10V
chicken	fat	500	T	8	43, 48	9V, 10V
cattle	milk	200	(µg/l) T	8	43, 48	9V, 10V

Febantel/Fenbendazole/Oxfendazole

ADI:	0-7 µg/kg body weight (1998) Group ADI
Residue Definition:	Sum of fenbendazole, oxfendazole and oxfendazole sulphone, expressed as oxfendazazole sulphone equivalents

Species	Tissue	MRL	(µg/kg)	Step	JECFA	CCRVDF
cattle	muscle	100		8	38, 45, 50	6V, 7V, 8V, 9V, 10V
pig	muscle	100		8	38, 45, 50	6V, 7V, 8V, 9V, 10V
sheep	muscle	100		8	38, 45, 50	6V, 7V, 8V, 9V, 10V
cattle	liver	500		8	38, 45, 50	6V, 7V, 8V, 9V, 10V
pig	liver	500		8	38, 45, 50	6V, 7V, 8V, 9V, 10V
sheep	liver	500		8	38, 45, 50	6V, 7V, 8V, 9V, 10V
cattle	kidney	100		8	38, 45, 50	6V, 7V, 8V, 9V, 10V
pig	kidney	100		8	38, 45, 50	6V, 7V, 8V, 9V, 10V
sheep	kidney	100		8	38, 45, 50	6V, 7V, 8V, 9V, 10V
cattle	fat	100		8	38, 45, 50	6V, 7V, 8V, 9V, 10V
pig	fat	100		8	38, 45, 50	6V, 7V, 8V, 9V, 10V
sheep	fat	100		8	38, 45, 50	6V, 7V, 8V, 9V, 10V
cattle	milk	100	(µg/l)	8	38, 45, 50	6V, 7V, 8V, 9V, 10V
sheep	milk	100	(µg/l)	8	38, 45, 50	6V, 7V, 8V, 9V, 10V

Neomycin

ADI:	0-60 µg/kg body weight (1996)
Residue Definition:	Neomycin.

Species	Tissue	MRL	(µg/kg)	Step	JECFA	CCRVDF
cattle	muscle	500		8	43, 47	9V, 10V
pig	muscle	500		8	43, 47	9V, 10V
sheep	muscle	500		8	43, 47	9V, 10V
goat	muscle	500		8	43, 47	9V, 10V
chicken	muscle	500		8	43, 47	9V, 10V
turkey	muscle	500		8	43, 47	9V, 10V
duck	muscle	500		8	43, 47	9V, 10V
cattle	liver	500		8	43, 47	9V, 10V
pig	liver	500		8	43, 47	9V, 10V
sheep	liver	500		8	43, 47	9V, 10V
goat	liver	500		8	43, 47	9V, 10V
chicken	liver	500		8	43, 47	9V, 10V
turkey	liver	500		8	43, 47	9V, 10V
duck	liver	500		8	43, 47	9V, 10V
cattle	kidney	10000		8	43, 47	9V, 10V
pig	kidney	10000		8	43, 47	9V, 10V
sheep	kidney	10000		8	43, 47	9V, 10V
goat	kidney	10000		8	43, 47	9V, 10V
chicken	kidney	10000		8	43, 47	9V, 10V
turkey	kidney	10000		8	43, 47	9V, 10V
duck	kidney	10000		8	43, 47	9V, 10V
cattle	fat	500		8	43, 47	9V, 10V
pig	fat	500		8	43, 47	9V, 10V
sheep	fat	500		8	43, 47	9V, 10V
goat	fat	500		8	43, 47	9V, 10V
chicken	fat	500		8	43, 47	9V, 10V
turkey	fat	500		8	43, 47	9V, 10V
duck	fat	500		8	43, 47	9V, 10V
cattle	milk	500	(µg/l)	8	43, 47	9V, 10V
chicken	eggs	500		8	43, 47	9V, 10V

Spectinomycin

ADI:	0-40 µg/kg body weight (1994)
Residue Definition:	Spectinomycin

Species	Tissue	MRL	(µg/kg)	Step	JECFA	CCRVDF
cattle	muscle	500		8	42, 50	8V, 9V, 10V
pig	muscle	500		8	42, 50	8V, 9V, 10V
chicken	muscle	500		8	42, 50	8V, 9V, 10V
cattle	liver	2000		8	42, 50	8V, 9V, 10V
pig	liver	2000		8	42, 50	8V, 9V, 10V
chicken	liver	2000		8	42, 50	8V, 9V, 10V
cattle	kidney	5000		8	42, 50	8V, 9V, 10V
pig	kidney	5000		8	42, 50	8V, 9V, 10V
chicken	kidney	5000		8	42, 50	8V, 9V, 10V
cattle	fat	2000		8	42, 50	8V, 9V, 10V
pig	fat	2000		8	42, 50	8V, 9V, 10V
chicken	fat	2000		8	42, 50	8V, 9V, 10V
cattle	milk	200	(µg/l)	8	42, 50	8V, 9V, 10V

Tilmicosin

ADI:	0-40 µg/kg body weight (1996)
Residue Definition:	Tilmicosin

Species	Tissue	MRL	(µg/kg)	Step	JECFA	CCRVDF
cattle	muscle	100		8	47	10V
pig	muscle	100		8	47	10V
sheep	muscle	100		8	47	10V
cattle	liver	1000		8	47	10V
pig	liver	1500		8	47	10V
sheep	liver	1000		8	47	10V
cattle	kidney	300		8	47	10V
pig	kidney	1000		8	47	10V
sheep	kidney	300		8	47	10V
cattle	fat	100		8	47	10V
pig	fat	100		8	47	10V
sheep	fat	100		8	47	10V
sheep	milk	50	(µg/l) T	8	47	10V