
Highly pathogenic avian influenza
Highly pathogenic avian influenza (HPAI) is a highly contagious transboundary disease with zoonotic potential affecting both animal and human health. It causes variable clinical signs and high mortality rates in both wild and domestic bird populations. Current H5 AI outbreaks have severely impacted countries globally, causing losses of rare and important wild bird species, as well as significant social and economic costs, including livelihood losses and egg shortages.
The spread of HPAI also strains poultry-related businesses, as measures such as culling and movement restrictions are necessary to contain the virus, which can disrupt the trade of poultry products. The ongoing devastation highlights the urgent need for improved control measures to prevent spillover and viral changes that could lead to a global pandemic. HPAI also infects mammals and humans, posing serious public health risks. Infected mammals include domestic cats, cattle, and wild animals such as foxes and seals, with human cases, although rare, occurring in those with close contact with infected poultry or environments.
Addressing these challenges requires a robust One Health approach. The FAO’s One Health Programme Priority Area (OHPPA), specifically the Better Production 3 (BP3) program, focuses on enhancing productivity and mitigating zoonotic infections risks like HPAI. It aims to strengthen early warning systems, improve biosecurity measures, and enhance preparedness and response to food chain emergencies. By promoting sustainable and inclusive food and agriculture supply chains, BP3 helps ensure resilient agrifood systems, while mitigating the impacts of HPAI.
FAO's role
Since 2004, FAO has worked globally to combat avian influenza (AI) by promoting biosecurity, improving disease control, and enhancing laboratory diagnostic capabilities through the One Health approach. In partnership with FAO/WOAH Reference Laboratories and other organizations, FAO monitors and assesses AI risks, providing laboratory protocols and sharing vital epidemiological and virological findings. FAO regularly issues updates on transboundary and emerging diseases, including AI, offering technical guidance and response recommendations.
Through the WOAH/FAO Network of Expertise on Animal Influenza (OFFLU), FAO coordinates efforts to prevent, detect, and control animal influenzas and collaborates with WHO on pandemic preparedness and risk assessment.
Did you know?
⦿ HPAI virus has spread worldwide and become endemic in poultry populations in many countries.
⦿ Since 2003, HPAI has led to the culling of hundreds of millions of birds worldwide to control outbreaks.
⦿ Outbreaks of HPAI have caused billions of dollars in economic losses due to the death of poultry, trade restrictions, and control measures.
⦿ The most notable subtypes of HPAI include H5N1, H7N9, and H5N8.
⦿ Surveillance and monitoring are essential for early detection and response to HPAI outbreaks.
Q&A

Q&A on avian influenza with FAO’s global surveillance coordinator on a perennial threat to human and animal health.
Situation updates
Featured resources

Elearning
Introduction to avian influenza: self-paced course
Tailored for veterinaries, veterinary paraprofessionals, and industry experts, this course provides crucial knowledge on global impact, detection methods, and prevention strategies.
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publication
A(H5N1) influenza in dairy cattle in the United States of America
This edition of EMPRES Watch focuses on the detection and subsequent spread of A(H5N1) in dairy cattle across the United States of America, and presents the latest updates on the risks and recommendations.
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publication
Global strategy for the prevention and control of highly pathogenic avian influenza (2024–2033). In brief
This four-pager document provides a high-level strategic direction to support and inform the development and/or revision of national and regional action plans for HPAI prevention and control.
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news
FAO publishes new guidelines for surveillance of influenza in cattle
Amid a wave of reported avian influenza infections of cattle and other mammals, FAO releases new guidelines advising its Members how to implement effective surveillance programmes for early detection of influenza in cattle.

news
Online training by FAO enhances the preparedness of European veterinarians against avian flu
FAO is offering online training to equip European veterinarians, who are the first responders, with the skills needed to detect and react to this cross-species virus, helping to mitigate severe health impacts on both animals and people.

news
Strengthening vaccination and surveillance strategies in the fight against avian influenza
The World Organisation for Animal Health (WOAH) and the International Alliance for Biological Standardization (IABS) recently hosted a meeting to share advancements and discuss strategies for surveillance in populations vaccinated for HPAI.