Vaccine Manual: the production and quality control of veterinary vaccines for use in developing countries

VACCINE MANUAL

The production and quality control of veterinary vaccines for use in developing countries

Table of Contents

Introduction	[741Kb]

PART I The induction of immunity by veterinary immunoprophylactics Genetically engineered vaccines Viral vaccines Bacterial vaccines Mycoplasmal vaccines Protozoal and rickettsial vaccines Multicellular parasite vaccines Conventional vaccines Special requirements for village chickens Fish vaccines Role of the Office International des Epizooties and International organizations in vaccine quality standardization	[4Mb]

PART II Registration, licensing, controls and practical issues related to veterinary vaccines The role of private industry in the transfer of vaccine technology to developing countries General design and operating requirements for vaccine manufacturing establishments Design, repair and maintenance of vaccine manufacturing establishments and equipment Aspects of financial management of veterinary vaccine manufacturing operations in developing countries The logistics of vaccine manufacture in developing countries	[2Mb]

PART III Basic laboratory services and media preparation for vaccine produtcion Modern cell culture technology for vaccine manufacture Fermentation technology for the production of bacterial vaccines The use of lyophilization in the manufacture of vaccines Viral vaccines Bacterial vaccines Adjuvants in veterinary vaccines Bottling, labelling and packaging of vaccines	[2Mb]

PART IV Quality assurance and good manufacturing practice The principles of good laboratory practices , including safety in vaccine production and quality control The role of reference and regional laboratories Description and documnetation of production and quality control of veterinary vaccines Assessment of potency in bacterial vaccines Potency control of modified live viral vaccines Potency assessment of inactivated viral vaccines In vitro potency testing of inactivated biologics: current situation in the European Union Sterility management and testing of vaccines and raw materials for adventitious agents	[3.5Mb]

Contributors	[1Mb]

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