This report illustrates how governments, health professionals, veterinarians and food producers can work together to implement greater disease prevention tools, reducing the need for antimicrobials on farms and transitioning towards healthier and more sustainable agrifood systems. The evidence and solutions presented align with the Reduce the Needfor Antimicrobials on Farms for Sustainable Agrifood Systems Transformation initiative (RENOFARM), coordinated by FAO, which aims to enroll 100 countries in the ten-year intiative.