Increasing pest and disease incidence due to changing climatic conditions is compelling farmers to use heavy doses of chemical fertilizers and pesticides to maintain their production. The intensive agricultural practices and excessive reliance on agrochemicals adversely affect the delicate and dynamic balance of the agroecosystems, impacting agricultural sustainability, environment, and human health. The International Rice Research Institute (IRRI) is promoting biopesticides and biofertilizers in Odisha together with Department of Agriculture and Farmers’ Empowerment (DAFE) to address this challenge.