Following a drought event, several interactive feedback relations will get involved, whose effects can be realized as drought impacts. That is the behaviour of the components of a socio-economic system in response to the new changes due to drought which will form the system total behaviour in terms of socioeconomic-natural responses and/or impacts. Developing relevant strategies to cope with system negative behaviours in a region, the research used a system dynamics approach to provide a unique framework for integrating the fragmented parts of physical and social systems to model the interactive feedback relations in Hamadan province in Iran.