Food safety and quality
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OECD Unique Identifier details

IND-1ØØØ3-4 x IND-1ØØ15-7
Commodity: Safflower
Traits: Bovine chymosin,Glufosinate tolerance
Name of product applicant: INDEAR S.A.
Summary of application:

This stacked event was generated from the conventional crossing of the parental events, using the same construction and the same procedure. Once the parental lines have been established, and their stability and similarity are confirmed, a conventional crossing is carried out to create the stacked event. Consequently, the safflower IND-1ØØØ3-4 x IND-1ØØ15-7 presents a phenotype similar to the parental events. The difference between the parental events and the accumulated one is the highest expression of seed chymosin, with the purpose that it was generated.
The safflower IND-1ØØØ3-4 x IND-1ØØ15-7 was developed with the aim of being an expression platform for the production of chymosin. Chymosin is the enzyme that induces the coagulation of milk in the cheese making process. The majority of the chymosin used in the dairy industry today (80-90%), is recombinant protein using genetically modified micro-organisms.

Date of authorization: 07/12/2017
Scope of authorization: Food and feed
Links to the information on the same product in other databases maintained by relevant international organizations, as appropriate. (We recommend providing links to only those databases to which your country has officially contributed.):
Summary of the safety assessment (food safety):
• Inheritance studies conducted indicated that Mendelian segregation exists. • New expression proteins are expressed in low levels. • It is compositionally equivalent to its non-transgenic counterpart. • No evidence of similarity or homology was found with known toxic proteins. • There is no evidence of expression of known allergenic substances for the proteins expressed in the event. • There is no hypothesis of risk that indicates that there are effects of metabolic interactions and between the proteins of the events when they are accumulated. It is concluded that the stacked event is substantially equivalent to its conventional counterpart, therefore, it is as safe and no less nutritious than conventional commercial varieties.
Where detection method protocols and appropriate reference material (non-viable, or in certain circumstances, viable) suitable for low-level situation may be obtained:
Relevant links to documents and information prepared by the competent authority responsible for the safety assessment: GMO commercial approvals in Argentina
GMO approvals for food/feed
Authorization expiration date (a blank field means there is no expiration date)
Organization/agency name (Full name):
Ministerio de Agroindustria
Contact person name:
Andrés Maggi
Physical full address:
Paseo Colón Avenue 367, 3° floor, City of Buenos Aires
Phone number:
54 11 5222 5986
Fax number:
Country introduction:

In Argentina, the food and feed risk assessment process of transformation events, as the result of modern biotechnology, is carried out by the National Service for Agrifood Health and Quality (Senasa). The General Office of Biotechnology, is the area responsible for carrying out this task. It has an specific professional team and the advise of a Technical Advisory Committee composed of experts from several scientific disciplines representing different sectors involved in the production, industrialization, consumption, research and development of genetically modified organisms.

Useful links
Relevant documents
Stacked events:

Stacked events with all single events approved, are assessed as a new event, but with much less requirements, always on a case-by-case basis.

Contact details of the competent authority(s) responsible for the safety assessment and the product applicant:

National Service for Agrifood Health and Quality (Senasa)