النسخة على الإنترنت: "مخلفات بعض العقاقير البيطرية في الأغذية والحيوانات" (الورقة الخاصة بالأغذية والتغذية رقم 41)

15-2013-zilpaterol-hydrochloride.pdf

18-2015-Zilpaterol HCL.pdf

The Committee reaffirmed the ADI of 0–0.04 µg/kg body weight established at the seventy-eighth meeting. The Committee established an ARfD of 0.04 µg/kg body weight based on a lowest-observed-adverse-effect level (LOAEL) of 0.76 µg/kg body weight for acute pharmacological effects observed in a single-dose human study, with application of an uncertainty factor of 20, comprising a default uncertainty factor of 10 for human individual variability and an additional uncertainty factor of 2 to account for use of a LOAEL for a slight effect instead of a NOAEL. The GEADE is 1.9 µg/day for the general population, which represents approximately 80% of the ARfD