Edición en línea: "Residuos en drogas veterinarias"

Ayuda en línea Terminology

Esta base de datos contiene la información más reciente sobre los niveles máximos de residuos en drogas veterinarias según lo recomendado por JECFA. Todas las monografías publicadas en la FAO sobre Alimentación y Nutrición, Papeles 41, son accesibles en formato electrónico. Estas monografías están sólo disponibles en inglés aunque algunas partes de la base de datos, como la página de preguntas y también una información básica se puede encontrar en árabe, chino, español, francés e inglés.

Medicamento veterinario

Imidocarb

La clase funcional

Antiprotozoal agent

Ultima evaluación

2003

Reunión de JECFA

IDA

0-10 µg/kg bw

Estatus de IDA

Full

Monografías de residuos

41-11-imidocarb_dipropionate.pdf

41-15-imidocarb.pdf

Definición del residuo

Parent drug

Límites máximos para residuos
(LMR) recomendados

Cattle	Fat	50 µg/kg	F
Cattle	Kidney	2000 µg/kg	F
Cattle	Liver	1500 µg/kg	F
Cattle	Milk	50 µg/kg	F
Cattle	Muscle	300 µg/kg	F

Otras observaciones

El resumen de la evaluación

In recommending MRLs, the Committee may take into account the following factors:
- An ADI of 0-10 mg/kg bw was established by the Committee at its 50th meeting, which results in an ADI of 0-600 mg for a 60 kg person.
- The percentages of marker residue to total residues determined in the study with radiolabelled compound considered by the Committee at its 50th meeting were as follows: liver 68%, kidney 88%, muscle 88% and milk 77%. As no data were available for fat, a factor based on the lowest ratio reported (in liver) was applied. The new data considered by the Committee at its present meeting confirmed the concentrations predicted from the data for total residues in fat using this factor. The present Committee rounded the percentages and assigned factors for correction of marker/total residues as follows: liver 0.7, kidney 0.9, muscle 0.9, fat, 0.7 and milk 0.8.
- The recommended MRLs are based on data resulting from the treatment of cattle with the recommended therapeutic dose of 3.0 mg/kg bw administered as a single subcutaneous injection.
- Imidocarb free base is the appropriate marker residue, as determined by the Committee at its fiftieth meeting.
- The new data on residue depletion indicate that kidney and muscle are the recommended target tissues.
- A suitable analytical method is available for analysis of imidocarb free base residues in edible tissues of cattle and cow's milk.
The recommended MRL's would result in a daily maximum intake of 523 mg, based on a daily food intake of 300 g of muscle, 100 g of liver, 50 g each of kidney and fat and 1.5 l of milk.
FNP 41/15