Edición en línea: "Residuos en drogas veterinarias"

Ayuda en línea Terminology

Esta base de datos contiene la información más reciente sobre los niveles máximos de residuos en drogas veterinarias según lo recomendado por JECFA. Todas las monografías publicadas en la FAO sobre Alimentación y Nutrición, Papeles 41, son accesibles en formato electrónico. Estas monografías están sólo disponibles en inglés aunque algunas partes de la base de datos, como la página de preguntas y también una información básica se puede encontrar en árabe, chino, español, francés e inglés.

Medicamento veterinario

Enrofloxacin

La clase funcional

Antimicrobial agent

Ultima evaluación

1997

Reunión de JECFA

IDA

0-2 µg/kg bw

Estatus de IDA

Full

Monografías de residuos

41-7-enrofloxacin.pdf

Definición del residuo

Límites máximos para residuos
(LMR) recomendados

Otras observaciones

The Committee postponed, at its 48th meeting, the evaluation of the residue data due to the late submission of important additional data.

El resumen de la evaluación

Based on the temporary ADI of 0-0.6 µg/kg for enrofloxacin established by the Committee, the permitted daily intake of parent drug and/or it sequivalents is 36 µg for a 60-kg person. In reaching its decision on the MRLs, the Committee considered thefollowing factors:
- The temporary ADI was based on a microbiological end-point.
- The quantification limits of the analytical methods (10 µg/kg for enrofloxacin and ciprofloxacin in tissues and 5 µg/kg in milk).
- The marker residue for tissues is the sum of the enrofloxacin and ciprofloxacin residues. Ciprofloxacin is the marker residue for bovinemilk.
- Neither the ratio of marker residue to total residues nor the percentage of total residues associated with antimicrobial activity was known.
- Since enrofloxacin and ciprofloxacin account for only 20% of total residues in pig liver, the intake of antimicrobially active residues could be up to five times the concentration of the marker residues.
The Committee noted that even if the MRLs were based on the limits of quantification of the most sensitive analytical methods multiplied by a factor of 2, the intake of marker residues from muscle, liver, kidney, fat, milk and eggs would be 39 µg, which is close to the maximum ADI of 36 µg. However, the Committee noted that the hypothetical MRLs based on the limits of quantification of the analytical method would not take intoaccount any antimicrobial activity of the significant fraction (up to 80%) forming the remaining residues. It therefore concluded that it was not possible to allocate MRLs to enrofloxacin.
TRS 855