Edition en ligne: "Résidus pour les médicaments vétérinaires"

Aide en ligne Terminology

Cette base de données contient l'information la plus récente sur les niveaux de résidus maximum pour les médicaments vétérinaires recommandés par JECFA. Toute la documentation publiée dans l'étude FAO Alimentation et Nutrition No. 41 est disponible en ligne en format numérique. Cette documentation existe seulement en Anglais, tandis que les pages d'information générale et une partie de la base de données sont traduites en Anglais, Français, Espagnol, Arabe et Chinois.

Médicament vétérinaire

Thiabendazole

Classe fonctionnelle

Antiparasitic

Dernière évaluation

2002

Réunion de JECFA

DJA

0-100 µg/kg bw

Statut de la DJA

Full

Monographies des résidus

41-5-thiabendazole.pdf

Définition du résidu

Sum of thiabendazole and5-hydroxythiabendazole

Limites maximales de résidu
(LMR) recommandés

Cattle	Fat	100 µg/kg	F
Cattle	Kidney	100 µg/kg	F
Cattle	Liver	100 µg/kg	F
Cattle	Milk	100 µg/kg	F
Cattle	Muscle	100 µg/kg	F
Goat	Fat	100 µg/kg	F
Goat	Kidney	100 µg/kg	F
Goat	Liver	100 µg/kg	F
Goat	Milk	100 µg/kg	F
Goat	Muscle	100 µg/kg	F
Pig	Fat	100 µg/kg	F
Pig	Kidney	100 µg/kg	F
Pig	Liver	100 µg/kg	F
Pig	Muscle	100 µg/kg	F
Sheep	Fat	100 µg/kg	F
Sheep	Kidney	100 µg/kg	F
Sheep	Liver	100 µg/kg	F
Sheep	Muscle	100 µg/kg	F

Autres remarques

Résumé de l'évaluation

In reaching its decision on MRLs, the Committee took into account the following:
- An ADI of 0-100 µg per kg of body weight was established. This would result in a maximum ADI of 6 mg for a 60 kg person.
- The total residues of thiabendazole can be approximated by the sum of the levels of thiabendazole and 5-hydroxythiabendazole and their conjugates.
- The sum of the residue levels of thiabendazole and 5-hydroxythiabendazole generally decreases to below 0.1 mgkg in all tissues and milk of animals within a few days of withdrawal. For a total daily food intake from 0.5 kg of edible tissues and 1.5 kg of milk containing 0.1 mg/kg of thiabendazole residues, the theoretical maximum daily intake for veterinary uses of tiabendazole would be:

(0.1 mg/kg X 0.5 kg tissue) + (0.1 mg/kg X 1.5 kg of milk) = 0.2 mg

This figure is much less than the value of 1.4 mg obtained by calculating theoretical maximum daily intakes based on other agricultural uses of thiabendazole. The theoretical maximum daily intake from alluses of thiabendazole corresponds to 27% of the maximum ADI.
At the 1975 Joint FAO/WHO meeting on pesticide residues, MRLs had been set for the edible tissues of cattle, goats, horses, pigs, and sheep at 0.1 mg/kg for the sum of thiabendazole and 5-hydroxythiabendazole.
The Committee recommended MRLs for thiabendazole plus 5-hydroxy-thiabendazole of 100 µg/kg for all edible tissues of cattle, goats, pigs, and sheep and milk of cattle and goats. Thiabendazole and 5-hydroxythiabendazole are joint marker residues.
TRS 832