Edition en ligne: "Résidus pour les médicaments vétérinaires"

Aide en ligne Terminology

Cette base de données contient l'information la plus récente sur les niveaux de résidus maximum pour les médicaments vétérinaires recommandés par JECFA. Toute la documentation publiée dans l'étude FAO Alimentation et Nutrition No. 41 est disponible en ligne en format numérique. Cette documentation existe seulement en Anglais, tandis que les pages d'information générale et une partie de la base de données sont traduites en Anglais, Français, Espagnol, Arabe et Chinois.

Médicament vétérinaire

Clenbuterol

Classe fonctionnelle

Beta-adrenoceptor agonist

Dernière évaluation

1996

Réunion de JECFA

DJA

0-0.004 µg/kg b

Statut de la DJA

Full

Monographies des résidus

41-9-clenbuterol.pdf

Définition du résidu

Parent drug

Limites maximales de résidu
(LMR) recommandés

Cattle	Fat	0.2 µg/kg	F
Cattle	Kidney	0.6 µg/kg	F
Cattle	Liver	0.6 µg/kg	F
Cattle	Milk	0.05 µg/l	F
Cattle	Muscle	0.2 µg/kg	F
Horse	Fat	0.2 µg/kg	F
Horse	Kidney	0.6 µg/kg	F
Horse	Liver	0.6 µg/kg	F
Horse	Muscle	0.2 µg/kg	F

Autres remarques

Résumé de l'évaluation

In reaching its decision on MRLs for clenbuterol, the Committee tookthe following factors into account:
- The ADI of 0-0.004 µg per kg of body weight per day, which is equivalent to a maximum ADI of 0.24 µg for a 60-kg person.
- Muscle and liver are the target tissues.
- The parent drug is the marker residue and is the only residue of public health concern. It accounts for 100% of the total residues in muscle, fat and milk (cows), 60% of the total residues in bovine liver and kidney, and 6% of the total residues in equine liver and kidney. Because the metabolites and bound residues are not of toxicological concern, they do not need to be taken into account in the calculation of the MRLs.
- Analytical methods suitable for regulatory use are available.
- The sponsor is not proposing to make the drug available for use in lactating cows.
The Committee was aware that clenbuterol has been used illegally as a growth-enhancing agent, primarily in cattle. When used for this purpose, it must be administered up to the time of slaughter. Residue studies conducted under these conditions are available, and both these and results of regulatory monitoring indicate that residues are likely to be substantially in excess of the MRLs, particularly in liver. The Committee recommended that clenbuterol should not be used as a growth-enhancing agent.
TRS 876