Edition en ligne: "Résidus pour les médicaments vétérinaires"

Aide en ligne Terminology

Cette base de données contient l'information la plus récente sur les niveaux de résidus maximum pour les médicaments vétérinaires recommandés par JECFA. Toute la documentation publiée dans l'étude FAO Alimentation et Nutrition No. 41 est disponible en ligne en format numérique. Cette documentation existe seulement en Anglais, tandis que les pages d'information générale et une partie de la base de données sont traduites en Anglais, Français, Espagnol, Arabe et Chinois.

Médicament vétérinaire

Doramectin

Classe fonctionnelle

Antiparasitic

Dernière évaluation

2004

Réunion de JECFA

DJA

0-1 µg/kg bw

Statut de la DJA

Full

Monographies des résidus

41-12-doramectin.pdf

41-8-doramectin.pdf

41-16-doramectin.pdf

Définition du résidu

Parent drug

Limites maximales de résidu
(LMR) recommandés

Cattle	Fat	150 µg/kg	F
Cattle	Kidney	30 µg/kg	F
Cattle	Liver	100 µg/kg	F
Cattle	Milk	15 µg/kg	F
Cattle	Muscle	10 µg/kg	F
Pig	Fat	150 µg/kg	F
Pig	Kidney	30 µg/kg	F
Pig	Liver	100 µg/kg	F
Pig	Muscle	5 µg/kg	F

Autres remarques

The Committee noted that on the basis of an MRL of 15mg/kg fordoramectin in whole milk in cattle, the milk discard times would be approximately 240 h according to the studies using the pour-on treatment. Milk discard times would be approximately 480 h after treatment using the dose formulated for injection. The Committee noted that the discard time necessary to accommodate the recommended MRL in milk was unlikely to be consistent with good veterinary practice.

Résumé de l'évaluation

In recommending MRLs for doramectin in milk, the Committee considered the following factors:
- The ADI for doramectin was 0-1 mg/kg bw, equivalent to an intake of up to 60 mg per day for a 60 kg person
- Based on MRLs for tissues in cattle and pigs, and the theoretical maximum daily intake of residues in tissue of 33 mg per day, approximately 27mg per day are available for milk.
- Based on its limited metabolism and the known large partitioning ratio for residues between milk fat and aqueous milk, the Committee considered that the ratio for marker residue to total residue for doramectin in milk would be equivalent to the ratio of doramectin residues in fat (0.80).
- The residue studies provided used a pour-on formulation at 0.58 mg/kg bw and the injectable formulation at 0.23 mg/kg, somewhat in excess of the recommended doses of 0.5mg/kg bw and 0.2 mg/kg bw, respectively.
- The marker residue is doramectin.
- A suitable analytical method is available for determining residuesin milk.
Based on the factors noted above, the Committee considered recommending an MRL on the basis of the available portion of doramectin residues permitted by the ADI. The Committee recommended an MRL of 15mg/kg, determined as doramectin. Taking into account the marker residue to total residue ratio in fat (0.8) and 1.5 kg of milk in the model food diet, this would be equivalent to 28mg. Total residues of doramectin for muscle, liver, kidney and fat tissues and cow's milk, estimated from the model food diet, would be 61mg/kg.
TRS 925