Edition en ligne: "Résidus pour les médicaments vétérinaires"

Aide en ligne Terminology

Cette base de données contient l'information la plus récente sur les niveaux de résidus maximum pour les médicaments vétérinaires recommandés par JECFA. Toute la documentation publiée dans l'étude FAO Alimentation et Nutrition No. 41 est disponible en ligne en format numérique. Cette documentation existe seulement en Anglais, tandis que les pages d'information générale et une partie de la base de données sont traduites en Anglais, Français, Espagnol, Arabe et Chinois.

Médicament vétérinaire

Levamisole

Classe fonctionnelle

Antiparasitic

Dernière évaluation

1994

Réunion de JECFA

DJA

0-6 µg/kg bw

Statut de la DJA

Full

Monographies des résidus

41-3-levamisole.pdf

41-6-levamisole.pdf

Définition du résidu

Parent drug

Limites maximales de résidu
(LMR) recommandés

Cattle	Fat	10 µg/kg	F
Cattle	Kidney	10 µg/kg	F
Cattle	Liver	100 µg/kg	F
Cattle	Muscle	10 µg/kg	F
Pig	Fat	10 µg/kg	F
Pig	Kidney	10 µg/kg	F
Pig	Liver	100 µg/kg	F
Pig	Muscle	10 µg/kg	F
Poultry	Fat	10 µg/kg	F
Poultry	Kidney	10 µg/kg	F
Poultry	Liver	100 µg/kg	F
Poultry	Muscle	10 µg/kg	F
Sheep	Fat	10 µg/kg	F
Sheep	Kidney	10 µg/kg	F
Sheep	Liver	100 µg/kg	F
Sheep	Muscle	10 µg/kg	F

Autres remarques

Résumé de l'évaluation

The following factors were taken into account in estimating the MRLs:
- The ADI
- The parent drug is a suitable marker residue and accounts for 2.4% of the total residues.
- All of the residues in muscle and fat are free residues and are equivalent to parent drug.
- Of the residues in liver, 50% are present in the bound fraction, and 15% of the bound residues are bioavailable.
- The residues in kidney are qualitatively similar to those in liver.
- It is assumed that all bioavailable residues in liver and kidney are equivalent to parent drug.
- The residues are similar in cattle, sheep and pigs.
Because residues at 1-day withdrawal in yolks of eggs laid by hens given the recommended dose were approximately 800 µg/kg, the Committee considered that levamisole should not be used in laying hens and did therefore not reconmend an MRL for eggs. No new data were submitted by the sponsors to support the re-evaluation of levamisole residues in milk. The Committee therefore withdrew the temporary MRL for milk, that was allocated at its thirty-sixth meeting. The sponsors recommend that levamisole should not be used in lactating cows.
If the recommended values are used for the MRLs and account is taken of the factors mentioned above, the theoretical maximum intake of residues of parent drug and its equivalents is 397 µg per day: of which only 14 µg is parent drug.
In view of the inherent variability involved in estimating total levamisole-equivalent residues based on levamisole as the marker residue and the fact that only a small proportion of the total residues is used to estimate the total levamisole equivalents, the Committee considered this value to be approximately the same as the ADI.
TRS 851