Edition en ligne: "Résidus pour les médicaments vétérinaires"

Aide en ligne Terminology

Cette base de données contient l'information la plus récente sur les niveaux de résidus maximum pour les médicaments vétérinaires recommandés par JECFA. Toute la documentation publiée dans l'étude FAO Alimentation et Nutrition No. 41 est disponible en ligne en format numérique. Cette documentation existe seulement en Anglais, tandis que les pages d'information générale et une partie de la base de données sont traduites en Anglais, Français, Espagnol, Arabe et Chinois.

Médicament vétérinaire

Imidocarb

Classe fonctionnelle

Antiprotozoal agent

Dernière évaluation

2003

Réunion de JECFA

DJA

0-10 µg/kg bw

Statut de la DJA

Full

Monographies des résidus

41-11-imidocarb_dipropionate.pdf

41-15-imidocarb.pdf

Définition du résidu

Parent drug

Limites maximales de résidu
(LMR) recommandés

Cattle	Fat	50 µg/kg	F
Cattle	Kidney	2000 µg/kg	F
Cattle	Liver	1500 µg/kg	F
Cattle	Milk	50 µg/kg	F
Cattle	Muscle	300 µg/kg	F

Autres remarques

Résumé de l'évaluation

In recommending MRLs, the Committee may take into account the following factors:
- An ADI of 0-10 mg/kg bw was established by the Committee at its 50th meeting, which results in an ADI of 0-600 mg for a 60 kg person.
- The percentages of marker residue to total residues determined in the study with radiolabelled compound considered by the Committee at its 50th meeting were as follows: liver 68%, kidney 88%, muscle 88% and milk 77%. As no data were available for fat, a factor based on the lowest ratio reported (in liver) was applied. The new data considered by the Committee at its present meeting confirmed the concentrations predicted from the data for total residues in fat using this factor. The present Committee rounded the percentages and assigned factors for correction of marker/total residues as follows: liver 0.7, kidney 0.9, muscle 0.9, fat, 0.7 and milk 0.8.
- The recommended MRLs are based on data resulting from the treatment of cattle with the recommended therapeutic dose of 3.0 mg/kg bw administered as a single subcutaneous injection.
- Imidocarb free base is the appropriate marker residue, as determined by the Committee at its fiftieth meeting.
- The new data on residue depletion indicate that kidney and muscle are the recommended target tissues.
- A suitable analytical method is available for analysis of imidocarb free base residues in edible tissues of cattle and cow's milk.
The recommended MRL's would result in a daily maximum intake of 523 mg, based on a daily food intake of 300 g of muscle, 100 g of liver, 50 g each of kidney and fat and 1.5 l of milk.
FNP 41/15