Edition en ligne: "Résidus pour les médicaments vétérinaires"

Aide en ligne Terminology

Cette base de données contient l'information la plus récente sur les niveaux de résidus maximum pour les médicaments vétérinaires recommandés par JECFA. Toute la documentation publiée dans l'étude FAO Alimentation et Nutrition No. 41 est disponible en ligne en format numérique. Cette documentation existe seulement en Anglais, tandis que les pages d'information générale et une partie de la base de données sont traduites en Anglais, Français, Espagnol, Arabe et Chinois.

Médicament vétérinaire

Lincomycin

Classe fonctionnelle

Antimicrobial agent

Dernière évaluation

2004

Réunion de JECFA

DJA

0-30 µg/kg bw

Statut de la DJA

Full

Monographies des résidus

41-16-lincomycin.pdf

41-13-lincomycin.pdf

41-14-lincomycin.pdf

Définition du résidu

Parent drug

Limites maximales de résidu
(LMR) recommandés

Cattle	Milk	150 µg/kg	F
Chicken	Fat	100 µg/kg	F
Chicken	Kidney	500 µg/kg	F
Chicken	Liver	500 µg/kg	F
Chicken	Muscle	200 µg/kg	F
Pig	Fat	100 µg/kg	F
Pig	Kidney	1500 µg/kg	F
Pig	Liver	500 µg/kg	F
Pig	Muscle	200 µg/kg	F

Autres remarques

A separate MRL of 300 mg/kg for skin with adhering fat in pigs was recommended in order to reflect the high concentrations found in the skin of pigs. For consistency, an MRL of 300 mg/kg for skin with adhering fat in chickens was also recommended.

Résumé de l'évaluation

In reviewing the MRLs recommended at its fifty-fourth meeting, the Committee at its present meeting took into account the following factors:
- The ADI of 0-30 mg/kg bw allocated by the Committee at its fifty-fourth meeting was based on a microbiological end-point. This ADI is equivalent to an acceptable maximum daily intake of 1800 µg of antimicrobially active residues of lincomycin for a 60 kg person.
- Parent lincomycin is the only residue with significant antimicrobial activity in tissues of chickens and pigs.
- Kidney and liver contain the highest concentrations of residues in chickens and pigs and pid=63155; however, the new studies confirmed that the concentrations of residues in kidney and liver are similar in chickens, but differ by a factor of three in pigs.
- The new studies suggest that the MRLs for skin/fat of chickens and for muscle of pigs should be higher than those recommended at the fifty-fourth meeting. The MRLs for fat could be maintained for bot hspecies, provided that a separate MRL was recommended for skin with adhering fat in pigs in order to reflect the high concentrations found in the skin of that species.
- For residue control programmes, it would be appropriate to harmonize the MRLs for chicken and pig tissues as far as possible.
- The temporary MRLs for tissues of cattle and sheep should be withdrawn, as the requested information was not provided.
- No data were provided on lincomycin residues in hen's eggs.
Daily consumption of 100 g of liver, 50 g of kidney, 300 g of muscle and 50 g of fat of pigs and 1500 g of cow's milk would result in a theoretical maximum daily intake of 415 µg per person per day or 23% of the ADI for a person with a body weight of 60 kg.
TRS 911