Безопасность и качество пищевых продуктов
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Online Edition: "Residues of some veterinary drugs in foods and animals"

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This database contains the most recent information on maximum residue levels for veterinary drugs as recommended by JECFA. All monographs published in the FAO Food and Nutrition Papers 41 can be accessed in an electronic format. These monographs are available only in English although some parts of the database, the query page as well as the background information are provided in English, French, Spanish, Arabic and Chinese.

Veterinary Drug Carbadox
Functional class Growth promoter
Latest evaluation 2003
JECFA meeting 60
ADI No ADI
ADI status None
Residue monographs  
Marker residue
Maximum residue limits
(MRL) recommended
Other remarks
Summary of the evaluation The new data confirm that carcinogenic residues, in particular desoxycarbadox, are present in edible tissues during the depletion of parent carbadox. The relatively long persistence of the residues was a new finding. The results also show that, after administration of the highest recommended dose of 55 mg/kg in feed, QCA depletes to below the MRL for liver recommended by the Committee at its 36th meeting within a short time (approximately 17 days on the basis of the upper limit of the 95% confidence interval on the 99th percentile).
As the Committee was unable to allocate an ADI for carbadox, there is no accepted reference point for comparison with the new data on residues. Therefore, on the basis of the new data, the MRL for QCA recommended by the Committee at its thirty-sixth meeting is not supported for determining residues of carbadox of toxicological concern in liver.
The MRL of 5 µg/kg recommended by the Committee at its thirty-sixth meeting for QCA in muscle is not supported by the new data. Desoxycarbadox was found at all times up to 15 days, but QCA was found in only two samples collected 0 and 3 h after withdrawal. Therefore, the relationship between the concentrations of QCA and desoxycarbadox is not known.
After reviewing the new studies, the Committee could not determine the amounts of residues of carbodox in food that would have no adverse health effects in consumers. The Committee decided to withdraw the MRLs of carbadox recommended by the Committee at its 36th meeting.
FNP 41/15