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Безопасность и качество пищевых продуктов
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Online help Terminology
This database contains the most recent information on maximum residue levels for veterinary drugs as recommended by JECFA. All monographs published in the FAO Food and Nutrition Papers 41 can be accessed in an electronic format. These monographs are available only in English although some parts of the database, the query page as well as the background information are provided in English, French, Spanish, Arabic and Chinese.
| Veterinary Drug |
Ceftiofur |
| Functional class |
Antimicrobial agent |
| Latest evaluation |
1997 |
| JECFA meeting |
48 |
| ADI |
0-50 µg/kg bw |
| ADI status |
Full |
| Residue monographs |
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| Marker residue |
Desfuroylceftiofur |
Maximum residue limits (MRL) recommended |
| Cattle | Fat | 2000 µg/kg | F | | Cattle | Kidney | 6000 µg/kg | F | | Cattle | Liver | 2000 µg/kg | F | | Cattle | Milk | 100 µg/l | F | | Cattle | Muscle | 1000 µg/kg | F | | Pig | Fat | 2000 µg/kg | F | | Pig | Kidney | 6000 µg/kg | F | | Pig | Liver | 2000 µg/kg | F | | Pig | Muscle | 1000 µg/kg | F |
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| Other remarks |
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| Summary of the evaluation |
In reaching its decision on the MRLs for ceftiofur, the Committee took into account the following: - The ADI for ceftiofur established by the 45th JECFA based on a microbiological end-point is 0-50 µg/kg of body weight. - A significant proportion of the total residue is considered to be inactive because the beta-lactam ring is no longer intact. MRLs are expressed as the marker residue, DFC, which accounts for all active residues and only these are used in calculating a theoretical daily exposure. - Residues measured as DFC are near or below 0.05 mg/kg (LOD) in muscle and fat and <0.5 mg/kg in/liver and kidney at 3 days after treatment in both cattle and pigs in studies provided. - Based on the depletion studies submitted marker residue in excess of the MRLs established for muscle and kidney by the 45th JECFA may be found in some treated pigs and cattle at 12 hours following final administration in accordance with recommended Good Veterinary Practices. - The MRLs were harmonized for pigs and cattle, on the basis of the depletion studies submitted. - The drug is used for therapeutic purposes only. - No new data were submitted on residue levels in milk. On the basis of the above considerations, the Committee recommended MRLs for ceftiofur, expressed as DFC, of 1000 µg/kg for muscle, 6000 µg/kg for kidney and 2000 µg/kg for fat in both cattle and pigs. The MRLs recommended by the 45th JECFA for ceftiofur of 2000µg/kg for liver in both cattle and pigs and 100 µg/l for cow's milk were reaffirmed. The MRLs recommended above would result in a theoretical maximum daily intake of 1050 µg of microbiologically active ceftiofur residues, expressed as desfuroylceftiofur, based on a daily food intake of 300 g of muscle, 100 g of liver, 50 g each of kidney and fat and 1.5 l of milk. FNP41/10 |
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