Безопасность и качество пищевых продуктов
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Online Edition: "Residues of some veterinary drugs in foods and animals"

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This database contains the most recent information on maximum residue levels for veterinary drugs as recommended by JECFA. All monographs published in the FAO Food and Nutrition Papers 41 can be accessed in an electronic format. These monographs are available only in English although some parts of the database, the query page as well as the background information are provided in English, French, Spanish, Arabic and Chinese.

Veterinary Drug Abamectin
Functional class Antiparasitic
Latest evaluation 1996
JECFA meeting 47
ADI 0-1 µg/kg bw
ADI status Full
Residue monographs  
Marker residue Avermectin B1a
Maximum residue limits
(MRL) recommended
CattleFat100 µg/kgF
CattleKidney50 µg/kgF
CattleLiver100 µg/kgF
Other remarks
Summary of the evaluation Considering that:
- the AD1 of 0-1 µg/kg bw established by JMPR results in a maximum allowable intake of residues of 0-60 µg for a 60 kg person
- Abamectin used as a veterinary drug is only intended for use in beef cattle
- Avermectin B1a is considered as the appropriate marker residue
- Liver and fat are considered as the appropriate target tissues
- Abamectin does not lead to bound residues in fat tissues and that bound residues account for less than 15% in liver
- Avermectin B1a accounts for 42% of the total residues in liver, 25% in fat tissue and 50% in kidney at 21 days post dosing
- There is an analytical method available

As abamectin is only intended for beef cattle, there is no need for an MRL in bovine milk. Recognizing that liver, kidney and fat are the only tissues appropriate for monitoring residues of abamectin in animal tissues, there is no need for an MRL in bovine muscle where residues deplete to non-detectable concentrations at the recommended withdrawal time. JECFA recognized that JMPR has established MRL's for abamectin used as pesticide that are suitable for residues in cattle muscle and milk. These MRLs result in a theoretical maximum daily intake of total residues of abamectin of 49 µg which, considering the total intake of 60 µg, gives an acceptable margin of safety for the possible additional ingestion of residues from pesticide use by consumption of fruits and vegetables and from the consumption of meat from cattle ingesting some contaminated fodder.
(FNP 41/9)