Безопасность и качество пищевых продуктов
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Online Edition: "Residues of some veterinary drugs in foods and animals"

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This database contains the most recent information on maximum residue levels for veterinary drugs as recommended by JECFA. All monographs published in the FAO Food and Nutrition Papers 41 can be accessed in an electronic format. These monographs are available only in English although some parts of the database, the query page as well as the background information are provided in English, French, Spanish, Arabic and Chinese.

Veterinary Drug Albendazole
Functional class Antiparasitic
Latest evaluation 1989
JECFA meeting 34
ADI 0-50 µg/kg bw
ADI status Full
Residue monographs  
Marker residue MRLs analysed as 2-amino-benzimidazo-le and expressed as parent drug equivalents, see WHO TRS 788
Maximum residue limits
(MRL) recommended
CattleFat100 µg/kgF
CattleKidney5000 µg/kgF
CattleLiver5000 µg/kgF
CattleMilk100 µg/kgF
CattleMuscle100 µg/kgF
SheepFat100 µg/kgF
SheepKidney5000 µg/kgF
SheepLiver5000 µg/kgF
SheepMilk100 µg/kgF
SheepMuscle100 µg/kgF
Other remarks
Summary of the evaluation The following factors were considered by the Committee in recommending MRLs for albendazole:
- The concentration of total residues is about 50 times greater inliver and kidney than in either muscle or fat.
- The estimated maximum daily intake of residues at four days withdrawal time or longer does not exceed the ADI.
- The concentration of total residues at ten days withdrawal time or longer does not exceed 5 mg/kg in liver or kidney or 0.1 mg/kg in muscle or fat.
- The residues at six days withdrawal time or longer contain low concentrations of toxic substances and pid=63155; there are no residues of parent drug and only small amounts of the sulfoxide metabolite.
- More than 95% of the residues at four days withdrawal time orlonger are bound residues, of which less than 15% are bioavailable.
- A withdrawal time of ten days is long enough for the drug to be efficacious and is compatible with good animal husbandry practice.
- The concentration of residues in milk declines rapidly following drug administration and is less than 0.1 mg/l by the fourth milking.
- The amount of residues in 1.5 l of milk obtained at the second milking is 0.8 mg of parent drug equivalent and, when added to the values for meat and offal at four days withdrawal time, the sum, 1.8 mg, is less than the ADI.
An MRL for total residues of albendazole of 0.1 mg/kg for muscle, fat and milk, and 5mg/kg for liver and kidney is recommended. In practice, the total residue is determined in tissues by measuring the residue of the 2-aminosulfone by means of an exhaustive extraction and liquid chromatographic procedure and multiplying the result by five for cattle and six for sheep. 2-aminobenzimidazole sulfone accounts for 20% and 17% of the total residue in liver from cattle and sheep, respectively.
TRS 788