Безопасность и качество пищевых продуктов
| share
 

Online Edition: "Residues of some veterinary drugs in foods and animals"

Online help   Terminology

This database contains the most recent information on maximum residue levels for veterinary drugs as recommended by JECFA. All monographs published in the FAO Food and Nutrition Papers 41 can be accessed in an electronic format. These monographs are available only in English although some parts of the database, the query page as well as the background information are provided in English, French, Spanish, Arabic and Chinese.

Veterinary Drug Benzylpenicillin
Functional class Antimicrobial agent
Latest evaluation 1990
JECFA meeting 36
ADI <30 µg/person/d
ADI status Full
Residue monographs  
Marker residue Parent drug
Maximum residue limits
(MRL) recommended
All speciesKidney50 µg/kgF
All speciesLiver50 µg/kgF
All speciesMilk4 µg/kgF
All speciesMuscle50 µg/kgF
Other remarks ADI expressed as the penicillin moiety
Summary of the evaluation In reaching a decision on a recommended MRL, the Committee considered the following points:
(a) The drug is used in both meat- and milk-producing animals.
(b) The maximum permitted daily intake of benzylpenicillin is 30 µg
.(c) Bioassay methods for screening benzylpenicillin are widely used and are likely to be the methods of choice for most Member States in the foreseeable future.
( d ) The analytical methods that are available for measuring residues in milk are much more sensitive than those for meat.
(e) Chemical assay methods for confirming bioassay results are becoming increasingly available, but at present they are less sensitive than bioassay methods.
An MRL for total residues of benzylpenicillin of 50 µg/kg forliver, kidney, and muscle (all species) and an MRL of 4 µg/kg for milk are recommended.
Thus, the estimated maximum daily intake of benzylpenicillin residues is 15 µg for muscle, 5 µg for liver, 3 µg for kidney, and 6 µg for milk, yielding a total maximum daily intake of 29 µg. The concentration of residues in fat is non-detectable.
TRS 799