Безопасность и качество пищевых продуктов
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Online Edition: "Residues of some veterinary drugs in foods and animals"

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This database contains the most recent information on maximum residue levels for veterinary drugs as recommended by JECFA. All monographs published in the FAO Food and Nutrition Papers 41 can be accessed in an electronic format. These monographs are available only in English although some parts of the database, the query page as well as the background information are provided in English, French, Spanish, Arabic and Chinese.

Veterinary Drug Carazolol
Functional class Beta-adrenoceptor blocking agent
Latest evaluation 1999
JECFA meeting 52
ADI 0-0.1 µg/kg bw
ADI status Full
Residue monographs  
Marker residue Parent drug.
Maximum residue limits
(MRL) recommended
PigFat/Skin5 µg/kgF
PigKidney25 µg/kgF
PigLiver25 µg/kgF
PigMuscle5 µg/kgF
Other remarks The Committee noted that the concentration of carazolol at the injection site may exceed the ADI which is based on the acute pharmacological effect of carazolol.
Summary of the evaluation The Committee established MRLs for carazolol based on the concentrations determined at 2 hours after administration in the HPLC study in pigs, which were 1.8 µg/kg for muscle, 9.9 µg/kg for liver, 6.9 µg/kg for kidney, and 1.8 µg/kg for fat. It concluded that the residue concentrations would be below the MRLs when, the drug is used according to the approved conditions of use. Using the concentrations of carazolol determined by HPLC at 2 hours after dosing and adding at least three statistical standard deviations, the Committee recommended MRLs in pigs of 5 µg/kg for muscle and fat/skin, and 25 µg/kg for liver and kidney, expressed as parent drug. These MRLs would result in a daily maximum intake of 5.5 µg of carazolol, based on a daily food intake of 300 g of muscle, 100 g of liver, and 50 g each of kidney and fat.
The Committee did not recommend MRLs for cattle.
TRS 855