Food safety and quality: details

兽药

Clenbuterol

功能分类

Beta-adrenoceptor agonist

最新评价

1996

食品添加剂和污染物联合专家委员会

每日允许摄入量

0-0.004 µg/kg b

每日允许摄入量状况

Full

残留量专题文集

41-9-clenbuterol.pdf

残留标示物

Parent drug

建议的最高残留限量

Cattle	Fat	0.2 µg/kg	F
Cattle	Kidney	0.6 µg/kg	F
Cattle	Liver	0.6 µg/kg	F
Cattle	Milk	0.05 µg/l	F
Cattle	Muscle	0.2 µg/kg	F
Horse	Fat	0.2 µg/kg	F
Horse	Kidney	0.6 µg/kg	F
Horse	Liver	0.6 µg/kg	F
Horse	Muscle	0.2 µg/kg	F

其他说明

评价概要

In reaching its decision on MRLs for clenbuterol, the Committee tookthe following factors into account:
- The ADI of 0-0.004 µg per kg of body weight per day, which is equivalent to a maximum ADI of 0.24 µg for a 60-kg person.
- Muscle and liver are the target tissues.
- The parent drug is the marker residue and is the only residue of public health concern. It accounts for 100% of the total residues in muscle, fat and milk (cows), 60% of the total residues in bovine liver and kidney, and 6% of the total residues in equine liver and kidney. Because the metabolites and bound residues are not of toxicological concern, they do not need to be taken into account in the calculation of the MRLs.
- Analytical methods suitable for regulatory use are available.
- The sponsor is not proposing to make the drug available for use in lactating cows.
The Committee was aware that clenbuterol has been used illegally as a growth-enhancing agent, primarily in cattle. When used for this purpose, it must be administered up to the time of slaughter. Residue studies conducted under these conditions are available, and both these and results of regulatory monitoring indicate that residues are likely to be substantially in excess of the MRLs, particularly in liver. The Committee recommended that clenbuterol should not be used as a growth-enhancing agent.
TRS 876

网络版“:食品和家畜中的一部分兽药残留”