Food safety and quality: details

兽药

Danofloxacin

功能分类

Antimicrobial agent

最新评价

1997

食品添加剂和污染物联合专家委员会

每日允许摄入量

0-20 µg/kg bw

每日允许摄入量状况

Full

残留量专题文集

41-10-danofloxacin.pdf

残留标示物

Parent drug

建议的最高残留限量

Cattle	Fat	100 µg/kg	F
Cattle	Kidney	400 µg/kg	F
Cattle	Liver	400 µg/kg	F
Cattle	Muscle	200 µg/kg	F
Chicken	Fat	100 µg/kg	F
Chicken	Kidney	400 µg/kg	F
Chicken	Liver	400 µg/kg	F
Chicken	Muscle	200 µg/kg	F
Pig	Fat	100 µg/kg	F
Pig	Kidney	200 µg/kg	F
Pig	Liver	50 µg/kg	F
Pig	Muscle	100 µg/kg	F

其他说明

For chickens fat/skin in normal proportion

评价概要

In reaching its decision on MRLs for danofloxacin, the Committeetook into account the following:
- An ADI of 0-20 µg per kg of body weight was established, based ona toxicological end-point. This would result in a maximum ADI of1200 µg for a 60-kg person.
- The parent drug is the marker residue.
- The metabolite desmethyldanofloxacin is considered to be tentimes as toxic as the parent drug.
- Only the toxicological activity of the parent drug and desmethyl-danofloxacin are known. Therefore all the residues, including thebound residues, are assumed to be of toxicological concern. The un-identified residues are assumed to have the same toxicity as theparent drug.
- Liver and muscle were considered to be the appropriate targettissues.
- Desmethyldanofloxacin occurs only in the liver.
- The proportion of the total residues accounted for by danofloxacin and desmethyldanofloxacin varies between different species.
The sum of all the residues covered by the AD1 expressed asdanofloxacin equivalents is given by the formula:
Total residues = residues of danofloxacin + unidentified residuesexpressed as danofloxacin equivalents + residuesof desmethyldanofloxacin expressed as danofloxacinequivalents.
TRS 879

网络版“:食品和家畜中的一部分兽药残留”