Food safety and quality: details

兽药

Doramectin

功能分类

Antiparasitic

最新评价

2004

食品添加剂和污染物联合专家委员会

每日允许摄入量

0-1 µg/kg bw

每日允许摄入量状况

Full

残留量专题文集

41-12-doramectin.pdf

41-8-doramectin.pdf

41-16-doramectin.pdf

残留标示物

Parent drug

建议的最高残留限量

Cattle	Fat	150 µg/kg	F
Cattle	Kidney	30 µg/kg	F
Cattle	Liver	100 µg/kg	F
Cattle	Milk	15 µg/kg	F
Cattle	Muscle	10 µg/kg	F
Pig	Fat	150 µg/kg	F
Pig	Kidney	30 µg/kg	F
Pig	Liver	100 µg/kg	F
Pig	Muscle	5 µg/kg	F

其他说明

The Committee noted that on the basis of an MRL of 15mg/kg fordoramectin in whole milk in cattle, the milk discard times would be approximately 240 h according to the studies using the pour-on treatment. Milk discard times would be approximately 480 h after treatment using the dose formulated for injection. The Committee noted that the discard time necessary to accommodate the recommended MRL in milk was unlikely to be consistent with good veterinary practice.

评价概要

In recommending MRLs for doramectin in milk, the Committee considered the following factors:
- The ADI for doramectin was 0-1 mg/kg bw, equivalent to an intake of up to 60 mg per day for a 60 kg person
- Based on MRLs for tissues in cattle and pigs, and the theoretical maximum daily intake of residues in tissue of 33 mg per day, approximately 27mg per day are available for milk.
- Based on its limited metabolism and the known large partitioning ratio for residues between milk fat and aqueous milk, the Committee considered that the ratio for marker residue to total residue for doramectin in milk would be equivalent to the ratio of doramectin residues in fat (0.80).
- The residue studies provided used a pour-on formulation at 0.58 mg/kg bw and the injectable formulation at 0.23 mg/kg, somewhat in excess of the recommended doses of 0.5mg/kg bw and 0.2 mg/kg bw, respectively.
- The marker residue is doramectin.
- A suitable analytical method is available for determining residuesin milk.
Based on the factors noted above, the Committee considered recommending an MRL on the basis of the available portion of doramectin residues permitted by the ADI. The Committee recommended an MRL of 15mg/kg, determined as doramectin. Taking into account the marker residue to total residue ratio in fat (0.8) and 1.5 kg of milk in the model food diet, this would be equivalent to 28mg. Total residues of doramectin for muscle, liver, kidney and fat tissues and cow's milk, estimated from the model food diet, would be 61mg/kg.
TRS 925

网络版“:食品和家畜中的一部分兽药残留”