Food safety and quality: details

兽药

Isometamidium

功能分类

Trypanocide

最新评价

1992

食品添加剂和污染物联合专家委员会

每日允许摄入量

0-100 µg/kg bw

每日允许摄入量状况

Full

残留量专题文集

41-5-isometamidium.pdf

41-2-isometamidium_chloride.pdf

残留标示物

Parent drug

建议的最高残留限量

Cattle	Fat	100 µg/kg	F
Cattle	Kidney	1000 µg/kg	F
Cattle	Liver	500 µg/kg	F
Cattle	Milk	100 µg/kg	F
Cattle	Muscle	100 µg/kg	F

其他说明

评价概要

Based on the AD1 of 0-100 µg/kg of body weight established by the Committee, the permitted daily intake of isometamidium would be 6 mg of total drug-related residue contributed by 500 g of meat together with 1.5 l of milk in the diet of a 60 kg person. From the study in bulls given isometamidium intramuscularly at 1 mg/kg bw, the Committee concluded that, at 30 days withdrawal time, the intake of residues of isometamidium would be well below the ADI. It therefore recommended an MRL of 0.1 mg/kg for parent isometamidium in muscle and fat, 0.5 mg/kg in liver, 1.0 mg/kg in kidney,and 0.1 mg/l in milk.
Concentrations of total residues at the injection site at 30 days withdrawal time averaged 96 mg/kg in the study in dairy cows and pid=63155; however, the Committee concluded that these residues would not adversely affect human food safety for the following reasons:
- Isometamidium residues in tissues are not bioavailable to any significant extent and pid=63155;
- Consumption of an injection site would be extremely rare and pid=63155; and
- the maximum theoretical intake of residues from muscle, liver, kidney, fat and milk of isometamidium at 30 days withdrawal time is well below the ADI.
TRS 832

网络版“:食品和家畜中的一部分兽药残留”