Food safety and quality: details

兽药

Streptomycin

功能分类

Antimicrobial agent

最新评价

2002

食品添加剂和污染物联合专家委员会

每日允许摄入量

0-50 µg/kg bw

每日允许摄入量状况

Full

残留量专题文集

41-7-dihydrostreptomycin_streptomycin.pdf

41-10-dihydrostreptomycin_streptomycin.pdf

41-12-dihydrostreptomycin_streptomycin.pdf

41-14-streptomycins.pdf

残留标示物

Sum of dihydrostreptomycin and streptomycin

建议的最高残留限量

Cattle	Fat	600 µg/kg	F
Cattle	Kidney	1000 µg/kg	F
Cattle	Liver	600 µg/kg	F
Cattle	Milk	200 µg/kg	F
Cattle	Muscle	600 µg/kg	F
Chicken	Fat	600 µg/kg	F
Chicken	Kidney	1000 µg/kg	F
Chicken	Liver	600 µg/kg	F
Chicken	Muscle	600 µg/kg	F
Pig	Fat	600 µg/kg	F
Pig	Kidney	1000 µg/kg	F
Pig	Liver	600 µg/kg	F
Pig	Muscle	600 µg/kg	F
Sheep	Fat	600 µg/kg	F
Sheep	Kidney	1000 µg/kg	F
Sheep	Liver	600 µg/kg	F
Sheep	Milk	200 µg/kg	F
Sheep	Muscle	600 µg/kg	F

其他说明

See dihydrostreptomycin/streptomycin

评价概要

At its present meeting, the Committee considered that the sponsors had provided satisfactory answers to all of its requests made at the forty-third meeting. It therefore decided to delete the temporary status of the MRLs, except that for milk. The MRLs for muscle, liver and fat were raised to 600 µg/kg, to take into account the twofold higher LOQ of the bioassay method compared with the HPLC method. The recommended MRL for kidney was 1000 µg/kg in cattle, pigs, sheep and chickens. The MRLs were expressed as the sum of the concentrations of dihydrostreptomycin and streptomycin.
From the above MRL values, the theoretical maximum daily intake of dihydrostreptomycin and streptomycin residues is 620 µg (equivalent to 21% of the maximum ADI), based on a daily food intake of 300 g of muscle, 100 g of liver, 50g each of liver and fat, and 1.5 kg of milk. If milk is excluded, the theoretical maximum daily intake is 320 µg or 11% of the ADI.
TRS 893.
The submitted HPLC method with fluorescence detection met the performance criteria for the analysis of dihydrostreptomycin and streptomycin in cow's and sheep's milk and was judged to be acceptable for routine monitoring of milk samples.
Although the study of residue depletion in sheep's milk had not been requested by the Committee, it provided the data needed to recommend an MRL for the combined residues of dihydrostreptomycin and streptomycin in sheep's milk. Therefore, the Committee recommended that the temporary designation for cow's milk of 200 µg/kg, measured as the combined residuesof dihydrostreptomycin and streptomycin, be removed and that theMRL of 200 µg/kg be extended to sheeps milk for the combined residues'of dihydrostreptomycin and streptomycin.
TRS 911

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