Food safety and quality: details

兽药

Triclabendazole

功能分类

Anthelminthic

最新评价

2011

食品添加剂和污染物联合专家委员会

每日允许摄入量

0-3 µg/kg bw

每日允许摄入量状况

Full

残留量专题文集

6-2009-triclabendazole.pdf

2-2006-triclabendazole.pdf

41-5-triclabendazole.pdf

12-2012-triclabendazole.pdf

残留标示物

Keto-triclabendazole

建议的最高残留限量

Cattle	Fat	100 µg/kg	F
Cattle	Kidney	400 µg/kg	F
Cattle	Liver	850 µg/kg	F
Cattle	Muscle	250 µg/kg	F
Sheep	Fat	100 µg/kg	F
Sheep	Kidney	200 µg/kg	F
Sheep	Liver	300 µg/kg	F
Sheep	Muscle	200 µg/kg	F

其他说明

评价概要

The bioavailabilities of [14C]-triclabendazole and [14C]-triclabendazole-derived incurred residues administered to rats by oral gavage was 70% and 9.2%, respectively. Based on these data, the relative oral bioavailability of incurred residues was 13%. In cattle, the ratios of marker residue concentration to total residue concentration were 0.32 for muscle, 0.19 for liver, 0.24 for kidney and 0.4 for fat on day 28. In sheep, the ratios were 0.4 for muscle, 0.25 for liver, 0.24 for kidney and 0.4 for fat (a conservative value based on that for fat from cattle). The kinetic behaviour of triclabendazole is distinctly different in cattle and sheep and there is no basis for establishing MRLs with the same numerical values for the two species.
The Estimated Daily Intake (EDI) was detemined using the median concentrations of marker residues in cattle tissues at day 28. The data for cattle were chosen for the EDI calculation because the concentration of median residues in all tissues was higher for cattle than for sheep. Accordingly, the EDI represents 47.4 % of the ADI.

网络版“:食品和家畜中的一部分兽药残留”