Food safety and quality: details

兽药

Imidocarb

功能分类

Antiprotozoal agent

最新评价

2003

食品添加剂和污染物联合专家委员会

每日允许摄入量

0-10 µg/kg bw

每日允许摄入量状况

Full

残留量专题文集

41-11-imidocarb_dipropionate.pdf

41-15-imidocarb.pdf

残留标示物

Parent drug

建议的最高残留限量

Cattle	Fat	50 µg/kg	F
Cattle	Kidney	2000 µg/kg	F
Cattle	Liver	1500 µg/kg	F
Cattle	Milk	50 µg/kg	F
Cattle	Muscle	300 µg/kg	F

其他说明

评价概要

In recommending MRLs, the Committee may take into account the following factors:
- An ADI of 0-10 mg/kg bw was established by the Committee at its 50th meeting, which results in an ADI of 0-600 mg for a 60 kg person.
- The percentages of marker residue to total residues determined in the study with radiolabelled compound considered by the Committee at its 50th meeting were as follows: liver 68%, kidney 88%, muscle 88% and milk 77%. As no data were available for fat, a factor based on the lowest ratio reported (in liver) was applied. The new data considered by the Committee at its present meeting confirmed the concentrations predicted from the data for total residues in fat using this factor. The present Committee rounded the percentages and assigned factors for correction of marker/total residues as follows: liver 0.7, kidney 0.9, muscle 0.9, fat, 0.7 and milk 0.8.
- The recommended MRLs are based on data resulting from the treatment of cattle with the recommended therapeutic dose of 3.0 mg/kg bw administered as a single subcutaneous injection.
- Imidocarb free base is the appropriate marker residue, as determined by the Committee at its fiftieth meeting.
- The new data on residue depletion indicate that kidney and muscle are the recommended target tissues.
- A suitable analytical method is available for analysis of imidocarb free base residues in edible tissues of cattle and cow's milk.
The recommended MRL's would result in a daily maximum intake of 523 mg, based on a daily food intake of 300 g of muscle, 100 g of liver, 50 g each of kidney and fat and 1.5 l of milk.
FNP 41/15

网络版“:食品和家畜中的一部分兽药残留”