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Report of the JECFA/JMPR Informal Harmonization Meeting. 1-2 February 1999, Rome, Italy








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    Residue Evaluation of Certain Veterinary Drugs. Joint FAO/WHO Expert Committee on Food Additives (JECFA). 75th Meeting. FAO JECFA Monographs 12 2012
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    The monographs in this volume of the FAO JECFA Monographs on the residues of, statements on, or other parameters of the veterinary drugs on the agenda were prepared by the invited experts for the Seventy-fifth Meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA), held in Rome, Italy, 7–17-November 2011. This was the nineteenth meeting of JECFA convened specifically to consider residues of veterinary drugs in food-producing animal species. The Committee had evaluated residues o f veterinary drugs at its 12th, 26th, 27th, 32nd, 34th, 36th, 38th, 40th,42nd, 43rd, 45th, 47th, 48th, 50th, 52nd, 54th, 58th, 60th, 62nd, 66th and 70th meetings (JECFA, various dates 1969–2010). The tasks for the Committee were to further elaborate principles for evaluating the safety of residues of veterinary drugs in food and for establishing acceptable daily intakes (ADIs) and recommend maximum residue limits (MRLs) for substances on the agenda when they are administered to food-producing an imals in accordance with good veterinary practice in the use of veterinary drugs. The enclosed monographs provided the scientific basis for the recommendations of MRLs. There is an important feature to bring to the attention of readers. This volume of the FAO JECFA Monographs is the third in a new format for the presentation of monographs from meetings of the Committee specifically devoted to residues of specific veterinary drugs in food. It was also the seventh meeting of JECFA subsequent to th e completion of the workshop to update the principles and methods of risk assessment for MRLs for pesticides and veterinary drugs, held jointly by FAO/RIVM/WHO, in Bilthoven, The Netherlands, 7– 11 November 2005. The outcomes of this workshop are incorporated in the Environmental Health Criteria, No. 240, publication Principles and methods for the risk assessment of chemicals in food, WHO, 2009. Specifically, the Committee continued to implement some of the more significant recommendations in th e workshop report, including the concept of using median residue values to estimate daily intakes of residues of veterinary drugs in food for chronic exposure intake estimates.
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    Residue evaluation of certain veterinary drugs. Joint FAO/WHO Expert Committee on Food Additives (JECFA). 66th meeting 2006 2006
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    The monographs in this volume of the FAO JECFA Monographs on the residues of, statements on, or other parameters of the veterinary drugs on the agenda were prepared by the invited experts for the sixty-sixth meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA) held in Rome, Italy, 22-28 February, 2006. This was the seventeenth meeting of JECFA convened specifically to consider residues of veterinary drugs in food animals. The Committee has evaluated residues of veterinary drug s in food animals at the 12th, 26th, 27th, 32nd, 34th, 36th, 38th, 40th, 42nd, 43rd, 45th, 47th, 48th, 50th, 52nd, 54th, 58th, 60th, and 62nd meetings (Ref. 1-15 and 19-22, respectively). The tasks for the Committee were to further elaborate principles for evaluating the safety of residues of veterinary drugs in food and for establishing acceptable daily intakes (ADIs) and recommend maximum residue limits (MRLs) for substances on the agenda when they are administered to food producing animals in accordance with good veterinary practice in the use of veterinary drugs. The enclosed monographs provided the scientific basis for the recommendations of MRLs. There are two significant items in this volume of the FAO JECFA Monographs to bring to the attention of readers. First, this volume is the first in a new format for the presentation of monographs from meetings of the Committee. Second, this was the first meeting of JECFA subsequent to the completion of the workshop to update the principl es and methods of risk assessment for MRLs for pesticides and veterinary drugs, held jointly by FAO/RIVM/WHO, in Bilthoven, The Netherlands, 7 - 11 November, 2005. Specifically, the Committee decided to implement one of the more significant recommendations in the workshop report – the concept of using median residue values to estimate daily intakes of residues of veterinary drugs in food for chronic exposure intake estimates (Ref. 24).
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    Residue Evaluation of Certain Veterinary Drugs. Joint FAO/WHO Expert Committee on Food Additives (JECFA). 70th meeting, 2008. FAO JECFA Monographs 6 2009
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    This document contains monographs on residue evaluations of certain veterinary drugs, prepared at the seventieh meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA), which was held in Geneva, Switzerland from 21 to 29 October 2008. Three substances were evaluated for the first time for the animal species concerned, avilamycin, monensin and narasin. Four substances were reassessed, dexamethasone, tilmicosin, triclabendazole and tylosin. The residue monographs provide informatio n on chemical identity and properties of the compounds, pharmacokinetics and metabolism, residue depletion studies and analytical methods validated and used for the detection and quantification of the compounds. In addition to these monographs, this document includes the considerations and recommendations developed by the Committee for residues of veterinary drugs in honey and possible approaches to derive MRLs for this commodity; and a monograph on residues in aquatic species of and an estimata tion of human dietary exposure to malachite green (an antimicrobial agent and contamimant). This publication and other documents produced by JECFA contain information that is useful to those who work with or are involved with recommending or controlling maximum residue limits for veterinary drugs in foods.

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