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ArticleThe COMBAT project: controlling and progressively minimizing the burden of vector-borne animal trypanosomosis in Africa
Version 2 (15 August 2022)
2022Also available in:
No results found.Vector-borne diseases affecting livestock have serious impacts in Africa. Trypanosomosis is caused by parasites transmitted by tsetse flies and other blood-sucking Diptera. The animal form of the disease is a scourge for African livestock keepers, is already present in Latin America and Asia, and has the potential to spread further. A human form of the disease also exists, known as human African trypanosomosis or sleeping sickness. Controlling and progressively minimizing the burden of animal trypanosomosis (COMBAT) is a fouryear research and innovation project funded by the European Commission, whose ultimate goal is to reduce the burden of animal trypanosomosis (AT) in Africa. The project builds on the progressive control pathway (PCP), a risk-based, step-wise approach to disease reduction or elimination. COMBAT will strengthen AT control and prevention by improving basic knowledge of AT, developing innovative control tools, reinforcing surveillance, rationalizing control strategies, building capacity, and raising awareness. Knowledge gaps on disease epidemiology, vector ecology and competence, and biological aspects of trypanotolerant livestock will be addressed. Environmentally friendly vector control technologies and more effective and adapted diagnostic tools will be developed. Surveillance will be enhanced by developing information systems, strengthening reporting, and mapping and modelling disease risk in Africa and beyond. The socio-economic burden of AT will be assessed at a range of geographical scales. Guidelines for the PCP and harmonized national control strategies and roadmaps will be developed. Gender equality and ethics will be pivotal in all project activities. The COMBAT project benefits from the expertise of African and European research institutions, national veterinary authorities, and international organizations. The project consortium comprises 21 participants, including a geographically balanced representation from 13 African countries, and it will engage a larger number of AT-affected countries through regional initiatives. -
Book (series)Expert consultation on the sustainable management of parasites in livestock challenged by the global emergence of resistance
Part 2: African animal trypanosomosis and drug resistance: a challenge to progressive, sustainable disease control
2022Also available in:
No results found.African animal trypanosomosis is a vector-borne disease transmitted by tsetse flies and other vectors in 37 African countries. Affecting livestock health and welfare, the disease imposes a heavy burden on communities that rely on domestic animals for their livelihoods. In most endemic areas, trypanosomosis control relies heavily on trypanocidal drugs, which are often the only tool farmers possess to manage the problem. Unfortunately, the few veterinary medicines to treat or prevent the disease are old and outdated, and their efficacy is challenged by the emergence and spread of resistant trypanosome strains. FAO convened experts to discuss how to control African animal trypanosomosis progressively and sustainably in the face of drug resistance. FAO organized the meeting in the framework of an Expert Consultation on the sustainable management of parasites in livestock challenged by the global emergence of resistance. The experts of animal trypanosomosis warned that over 17 countries in Africa have reported treatment failure possibly resulting from trypanocidal drug resistance, which hampers disease control and negatively affects food security and livelihoods. Several factors contribute to the emergence and spread of trypanocidal drug resistance, including drug overuse and misuse, the circulation of fake or substandard products and weak controls along the supply chains. The meeting recommended that national authorities should promote the quality control of trypanocides, raise awareness of rational drug use and strengthen data collection and surveillance. FAO and the other organizations of the Tripartite should develop and disseminate guidelines and best practices, provide a platform for technical and scientific discussions, and they should support advocacy, awareness and resource mobilization at the international level. Academic institutions should improve our understanding of the mechanisms and drivers of resistance and develop more effective tools to monitor and curb the spread of the problem. -
Book (series)Introduction and spread of lumpy skin disease in South, East and Southeast Asia
Qualitative risk assessment and management
2020Also available in:
No results found.Lumpy skin disease (LSD) is a vector-borne disease of cattle and Asian water buffalo that is included on the OIE (World Organisation for Animal Health) list of notifiable diseases. In July 2019 LSD was introduced to Bangladesh, China and India and then spread to Nepal and Bhutan and in 2020 to various provinces of China and India. A qualitative risk assessment was conducted to assess the likelihood of introduction and/or spread of LSD in 23 countries in South, East and Southeast Asia based on information available up to 31 October 2020. The economic impact of LSD for South, East and Southeast countries was estimated to be up to USD 1.45 billion in direct losses of livestock and production. These losses may be higher, due to the severe trade implications for infected countries. This document provides an overview of LSD control approaches, including prevention. The cost-effectiveness estimation demonstrates a strong economic justification for vaccination and advocates for a regional approach to harmonize control measures.
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