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Guidelines on monitoring antimicrobial use at the farm level

Regional Guidelines for the Monitoring and Surveillance of Antimicrobial Resistance, Use and Residues in Food and Agriculture – Volume 5








  • conducting a situational analysis;
  • establishing an operational mechanism;
  • technical preparation.
The recommendations cover both terrestrial and aquatic food-producing animals and consider the wide range of AMU monitoring capacities in Asia and the Pacific and beyond. The target users of this guideline are the competent authorities, research institutions and agrifood industry actors who plan to develop or improve an AMU monitoring system at the farm level.


Related guidelines for the monitoring and surveillance of antimicrobial resistance, use and residues in food and agriculture:

Last updated 23/02/2024, see Corrigendum


FAO & WOAH. 2023. Guidelines on monitoring antimicrobial use at the farm level – Regional Guidelines for the Monitoring and Surveillance of Antimicrobial Resistance, Use and Residues in Food and Agriculture. Volume 5. Bangkok.



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    Antimicrobial resistance (AMR) is a growing global threat. Although much of it can be attributed to the (mis)use of antimicrobials in humans, the overuse of drugs in food animal production also threatens the effective treatment of human and animal diseases. Only limited data on the use of antimicrobials in food animals in Thailand and the Asia and Pacific region are available. However, indirect evidence indicates the widespread misuse of antimicrobials in animal production in the country and region. Awareness of the threat of AMR development and spread is low among public authorities and professionals involved with animal production, and few countries in the region have systems in place to monitor antimicrobial use (AMU) and AMR, carry out risk assessments and develop evidence-based policies for AMR risk management. The project was aimed at assisting the Government of Thailand to contain the spread of AMR in the country through enhanced and harmonized national capacity for AMU and AMR monitoring and AMR risk management, following international guidelines and standards. Project outputs included the development of education and information materials on AMR, guidelines and capacity development activities to reduce the risk of AMR, and the establishment of sample protocols and laboratory diagnostics.
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    Protocol on estimation of antimicrobial usage at farm level 2024
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    Antimicrobial resistance (AMR) is acknowledged as one of the main threats to human health worldwide. It is widely recognized that antimicrobial use (AMU) leads to the selection of resistant bacteria, and that animals may constitute one of the reservoirs of resistant bacteria and resistance genes. Recently, an association between the use of certain antimicrobials in animals and the occurrence of AMR in few clinical isolates from humans has beenshown. Consequently, reducing AMU in both humans and animals is an essential step toward limiting AMR in both humans and animals. Monitoring AMU at farm or prescriber level offers the ability to pinpoint ‘non-prudent’ or excessive AMU and can help guide farm-specific preventive or corrective actions. The information arising from farm-level AMU monitoring is critical for driving antimicrobial stewardship, i.e. the establishment and implementation of measures aimed at combating AMR by promoting responsible AMU practices. This protocol for estimation of AMU at the farm level addresses: (1) data collection, (2) data analysis (i.e. the calculation of indicators to quantify AMU), and (3) reporting the results, as all are important elements in advancing antimicrobial stewardship. Each of these elements can be approached in different ways, with several decisions to be made along the way. These practical guidelines are intended to provide design for farm-level AMU monitoring. It will help to provide data on the type and detail(s) of the antibiotic(s) used and the indicators for reporting results.
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    Monitoring and surveillance of antimicrobial resistance in bacterial pathogens from aquaculture
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    The guidelines provide a regional overview of antimicrobial resistance (AMR) surveillance in aquaculture, including the importance of harmonizing methodologies across the region (Chapter 1). The guidelines also cover approaches to the design of AMR surveillance in aquaculture, from identifying the target population to sampling considerations (Chapter 2). Sample consideration and transport are described in detail, following standing methodologies for disease surveillance in aquaculture (Chapter 3). The laboratory methods are described, from general principles to specific methodologies (Chapter 4). Finally, the guidelines also describe AMR data management including collection, storage, analysis, and presentation (Chapter 5). While Volume 3 provides guidance for carrying out AMR monitoring and surveillance in aquaculture, the other areas in the AMR surveillance framework are covered in the respective volumes of this regional guideline series: Volume 1 (Monitoring and surveillance of antimicrobial resistance in bacteria from healthy food animals intended for consumption), Volume 2 (Monitoring and surveillance in animal pathogens recovered from diseased livestock); Volume 4 (Monitoring bacterial resistance in the animal environment) that will focus on monitoring AMR in bacteria from agriculture settings (such as manure and slurry in livestock farms and aquatic environments), Volume 5 (Monitoring antimicrobial usage in animals at the farm level) and Volume 6 (Monitoring antimicrobial residues in food). Experts from FAO, the Singapore Food Agency and the Singapore National Parks Board led the writing of this volume.

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