This work aims at analyzing different management practices for the improvement of the agricultural production in the Central Jordan Valley. The optimization of the cropping pattern has been done under different water scarcity and drought conditions and prevailing environmental and socio-economic constraints. The ISAREG model was used to estimate crop water requirements, net irrigation requirements and to develop the crop response to water curves under open field and greenhouse conditions, taking into account actual soil and water salinity level. A socio-economic model was developed in order to optimize the cropping pattern and to evaluate water productivity, land use and farmer's profit under different water availability and water prices scenarios. The overall results indicated that the reduction of water availability is the most limiting factor of the agricultural production in the region which might lead to the reduction of the cultivated land and profits. However, water productivity is not affected significantly neither by the restrictions of water supply not by the increase of water tariffs. The cultivation of less water demanding and salt tolerant vegetables, especially under greenhouse conditions, as well as the application of deficit irrigation practices are recommended to adapt to drought situations