The Guidelines for action on food loss and waste reduction in the Near East and North Africa provide support to Member Countries to implement the Voluntary Code of Conduct for Food Loss and Waste Reduction, an international instrument designed to guide FLW policymaking and interventions at global level. These regionally-tailored Guidelines offer a basis for developing national strategies, policies, and legislation enabling food loss and waste reduction in line with national agrifood system objectives of NENA countries. The actions and principles put forward herein have the ultimate goal of accelerating the region’s transition to sustainable and resilient agrifood systems.