Food and nutrition insecurity has been a major challenge in Sub-Saharan Africa (SSA). With land frontier closing, farmers in SSA must intensify and diversify food production to alleviate food and nutrition insecurity. In the face of climate change, African Indigenous Vegetables (AIVs) can offer opportunities to diversify production systems and improve food, nutrition and income security in many countries of SSA. Despite their potential, the importance of AIVs in alleviating food, nutrition and economic insecurity are not fully exploited in Kenya. Further until recently there is less research and development efforts and limited information on farmers’ knowledge, attitude and perceptions about AIVs. The objective of this study was to assess the knowledge, attitude and practice among AIVs farmers in three counties (Busia, Nyamira and Machakos) of Kenya and analyzed the critical factors influencing KAP. The study was carried out on 600 farm households. The formula by Cochran was used to estimate the sample size. A multi-stage sampling procedure was used to select counties, villages and smallholder AIVs growers. Counties were selected purposively based on their different agro-ecological characteristics. These counties are; Nyamira (the Agro-Alpine Zone), Busia (the Medium Potential zone) and Machakos (the Semi-Arid zone). Villages were randomly selected from these three counties. Lists of AIVs farmers were prepared with assistance of village leaders and farmers randomly selected for interview. Farmers were interviewed on their farms. Knowledge and attitude were assessed on a 3 and 5 point Likert scale, respectively while closed and openended questions were used to evaluate the practice.