Tsetse flies live in 36 countries and a total area of between 9 and 10 million square kilometres in Africa. Throughout this area the disease transmitted by the tsetse fly, Trypanosomiasis (or Trypanosomosis), has a significant effect on large numbers of livestock. About 50 million cattle and tens of millions of small ruminants are considered to be at risk from Trypanosomiasis. The disease is considered as an obstacle to poverty reduction and food security in Africa. In addition, according to the World Health Organization (WHO), more than 60 million people, mainly living in the rural areas of sub-Saharan Africa, are at risk of Trypanosomiasis, or sleeping sickness. An interactive programme has been developed to assess the impact of control operations on tsetse populations in relatively homogeneous savanna habitats of Eastern and Southern Africa. Tsetse Muse is designed to help planners choose strategies for controlling tsetse from a range of currently available techniques. The programme allows the user to define the parameters of a tsetse population and then view the impact and cost- effectiveness of different control strategies, including combinations of different techniques.