This article reviews the main initiatives underlying ecologically intensive agroecosystems, analyses basic concepts, and proposes a framework for action. The rainforest model, the dry forest model, and the American Prairie are exemplified as three main natural systems at the basis of the mimicry concept. The link between biodiversity and the mimicry hypotheses, and the use of the concepts of productivity, efficiency, stability, and resilience for agroecosystems are discussed. Six main principles for cropping system design based on natural ecosystem mimicry are identified. A three-step framework for action is proposed, including nature observation, experimental design, and participatory design. Although far from being a panacea, the mimicry approach can provide new ways for agroecosystem design both in temperate and tropical countries.