Global agriculture and food systems are not on track to achieve the targets set by Agenda 2030 to achieve zero hunger and eradicate malnutrition by 2030. There is an urgent need to develop strategies that can provide enough nutritious food for all in a manner that enhances livelihoods and does not damage the environment and human health. The Economics of Ecosystems and Biodiversity for Agriculture and Food Systems (TEEBAgriFood) program took a holistic approach to examining agriculture so that appropriate policy responses can be developed to fix our broken food systems. TEEBAgriFood systematically identifies material links that food systems have with several dimensions of human well-being.  This study examines the economic, social, and health impacts of Andhra Pradesh Community Managed Natural Farming (APCNF; hereafter CNF) compared to three different farming systems prevalent in the state of Andhra Pradesh, India: low-input farming in the montane-forested tribal region, low-input rainfed farming in the semi-arid southwestern region, and high-input farming in the Krishna-Godavari delta region.  We have gathered strong evidence that CNF offers a better alternative to the existing and still dominant farming systems across all three agroecological regions. The adoption of CNF has led to improvements in crop diversity, comparable or higher yields, higher incomes, lower input costs, improved social capital, and improved health, and correlates with lower health costs in all three regions that were analyzed. Overall, CNF gives positive returns on public investment. Social capital compensated for the lack of education and experience, enabling the CNF farmers to reap productivity gains. The average economic loss was highest in villages where chemically intensive farming was practised, proving CNF to be the food production system with better returns both in terms of farm economics and human well-being.