#623 Delayed neurotoxicity following acute exposure (hen)
Objective of the study
The objective of this delayed neurotoxicity study is to assess the potential of certain classes of substances to cause delayed neurotoxicity or delayed polyneuropathy following acute exposure.
Circumstances under which the study is recommended to be required
The delayed neurotoxicity study following acute exposure is recommended if the test material is an organophosphorus substance, which includes uncharged organophosphorus esters; thioesters or anhydrides of organophosphoric, organophosphonic, or organophosphoramidic acids; or of related phosphorothioic, phosponothioic, or phosphorothioamidic acids; or is structurally related to other substances that may cause the delayed neurotoxicity sometimes seen in this class of chemicals.
Test organism
The delayed neurotoxicity study is conducted with the adult domestic hen.
Test substance
Technical grade active ingredient
Typical endpoints of the study
Typical endpoints of the delayed neurotoxicity study include (among others):
- toxic response data, including mortality;
- nature, severity and duration of clinical observations (whether reversible or not);
- biochemical findings.
Test guidelines
The following test guidelines may be used for the delayed neurotoxicity study following acute exposure:
- OECD Guidelines for the Testing of Chemicals. Test No. 418: Delayed neurotoxicity study of organophosphorous substances following acute exposure
- US EPA Health Effects Test Guidelines. OPPTS 870.6100 Acute and 28-day delayed neurotoxicity of organophosphorus substances
- EC Testing Method B.37. Delayed neurotoxicity of organophosphorus substances after acute exposure. Council Regulation (EC) No 440/2008.