The Food and Agriculture Organization of the United Nations (FAO) has embraced South-South and triangular cooperation (SSTC) as a key delivery modality to catalyse agricultural development, food security, rural development, poverty reduction and nutrition over the past two decades. FAO has strengthened its support for SSTC since 2012, and the SSTC portfolio has been expanding in line with the progressive institutionalization of SSTC in FAO. The main objective of the new SSTC Guidelines for Action is to develop a results-focused vision and structure, providing strategic direction for FAO’s SSTC programme and strengthening FAO’s position as global advocate, convener, broker, facilitator and enabler of SSTC in the area of agri-food systems.