The excessive use of pesticides has multiple adverse effects on the environment and human health. For a long time this problem was focused on the technical, agronomic, medicinal and pest management’s aspects, while the problem is a behavioral problem and the socio-economic aspect plays an important role. In order to study the Farmers’ risk perceptions of pesticides used in agriculture greenhouses in central-eastern Tunisia (Monastir Governorate), an ordered probit model was tested for 110 farms for greenhouse agriculture.  The results showed the significance and positivity of the relationship between independent variables such as extension, use of protective equipment, experience, membership of the public irrigation perimeter, agricultural income, and the variable depending on Farmers’ risk perceptions of pesticides used. On the other hand, absence of the relationship between the level of education and the perception that it seems contradictory, but it can be justified by the age of the farmers who is high. The overall significance of the ordered probit model with a perceived acceptable level of perception can be improved by taking into account the heterogeneity of the farmers in this region in terms of age, education level, membership in a public or private irrigation perimeter and the possibility of access to extension. Developing awareness-raising methods are based on demonstrative and simple techniques accompanied by optimal monitoring and control can reduce the rate of excessive use of pesticides and guarantee greenhouse agriculture sustainable in the central eastern region of Tunisia.