9 May 2024, 08:30 hours; Rome
Situation: High pathogenicity avian influenza (HPAI) virus (H5, H5N1, H5N2, H5N6, H5N8, H7 and H7N6 subtypes) with pandemic potential in countries of Sub-Saharan Africa since February 2017.
Confirmed countries (H5): South Africa*
Confirmed countries (H5N1): Benin, Botswana, Burkina Faso*, Cameroon, Côte d’Ivoire, Réunion (France), Gambia, Gabon, Ghana, Guinea, Lesotho, Mali, Mauritania, Namibia, Niger*, Nigeria*, Senegal, South Africa, and Togo.
Confirmed countries (H5N2): Nigeria and South Africa.
Confirmed countries (H5N6): Nigeria.
Confirmed countries (H5N8): Cameroon, Democratic Republic of the Congo, Namibia, Niger, Nigeria, South Africa, Uganda, and Zimbabwe.
Confirmed countries (H7): Mozambique*
Confirmed countries (H7N6): South Africa*
Animal findings: 2 new events since the last update on 12 April 2024.
Number of human cases: 0 new events since last update (Last reported case 10 November 2021).
*Countries reporting cases in current wave (since 1 October 2023).
Map. Officially reported HPAI outbreaks (H5, H5N1, H5N2, H7 and H7N6 subtypes) in sub-Saharan Africa, by onset date (1 October 2023 to date)
Note: Map A shows confirmed HPAI events observed from 1 October to 9 May 2024 (current wave).
Map B shows HPAI events observed from 1 October 2022 to 30 September 2023 (previous wave).
Table. High pathogenicity avian influenza events reported in animals since 1 October 2023 (i.e. current wave)
Virus | Country (administrative regions affected) |
Last event observed | #Events since last update | Total #events since 1 October 2023 | Species affected since the last update or during the last observed events |
---|---|---|---|---|---|
H5 |
South Africa |
29/02/2024 |
1 |
23 |
Commercial ostrich, poultry, Jackass Penguin, Swift Tern |
H5N1
|
Nigeria |
27/02/2024 |
0 |
3 |
Geese, Captive peacocks |
Burkina Faso |
01/03/2024 |
0 |
1 |
Poultry |
|
Niger |
27/01/2024 |
0 |
1 |
Domestic poultry |
|
H7 |
Mozambique |
29/09/2023 |
0 |
1 |
Layer chicken |
H7N6 |
South Africa |
18/12/2023 |
1 |
66 |
Domestic poultry and domestic non-poultry birds |
For a summary of H5N1, H5N6, and H5N8 HPAI events reported in sub-Saharan African countries in previous waves (i.e. before 1 October 2023) please contact EMPRES-Animal Health
Bedair, N.M., Sakr, M.A., Mourad, A., Eissa, N., Mostafa, A. & Khamiss, O. 2024. Molecular characterization of the whole genome of H9N2 avian influenza virus isolated from Egyptian poultry farms. Archives of Virology, 169(5): 99. reference In this study, we sequenced the genome of an H9N2 avian influenza virus (AIV) isolated from chickens in Egypt in 2021. Phylogenetic analysis placed the strain within the G1 sublineage of the Eurasian lineage. While some segments were related to Egyptian genotype II, others were related to genotype I. Molecular analysis revealed mutations in the HA protein suggesting a preference for human-like receptors and changes in antigenic sites. Mutations in the NA protein were reminiscent of past human pandemic strains. Internal proteins showed virulence markers, indicating intrasubtype reassortment and potential for increased virulence. These findings underscore the evolving nature of AIV H9N2 and raise concerns about its future pathogenicity for both poultry and humans.
Kutkat, O., Gomaa, M., Aboulhoda, B.E., Moatasim, Y., El Taweel, A., Kamel, M.N., El Sayes, M., et al. 2024. Genetic and virological characteristics of a reassortant avian influenza A H6N1 virus isolated from wild birds at a live-bird market in Egypt. Archives of Virology, 169(5): 95. reference The first human infection with avian influenza A/H6N1 in Taiwan in 2013 raised concerns about this virus. During routine surveillance in Egyptian live-bird markets, an H6N1 virus was isolated from a garganey duck and characterized as A/Garganey/Egypt/20869C/2022(H6N1). Phylogenetic analysis revealed a unique genomic makeup, with segments inherited from various subtypes previously found in Egypt and Eurasian countries. Replication kinetics in mammalian cell lines (A549, MDCK, and Vero cells) showed efficient replication in C57BL/6 mice without prior adaptation, with faster growth and higher titers than the ancestral strain A/Quail/HK/421/2002(H6N1). These findings suggest that reassortant H6 AIVs could pose a threat to human health, emphasizing the importance of ongoing surveillance for H6 Avian Influenza virus in nature.
Olawuyi, K., Orole, O., Meseko, C., Monne, I., Shittu, I., Bianca, Z., Fusaro, A., et al. 2024. Detection of clade 2.3.4.4 highly pathogenic avian influenza H5 viruses in healthy wild birds in the Hadeji-Nguru wetland, Nigeria 2022. Influenza Other Respiratory Viruses, 18(2): e13254. reference In Nigeria, multiple avian influenza virus (AIV) subtypes have caused poultry outbreaks, potentially linked to trade and wild birds. A study at the Hadejia-Nguru wetlands collected 452 swabs from wild aquatic birds, identifying highly pathogenic H5N1 AIV in clinically healthy species. Prevalence was 11.1%, with phylogenetic analysis showing clade 2.3.4.4b. These viruses differed from those in Nigerian poultry, suggesting separate introductions. Whole-genome characterization revealed mammalian adaptive marker E627K in Afro-tropical resident aquatic ducks, indicating zoonotic potential. Surveillance in wild birds is crucial for monitoring virus diversity, enhancing epidemiological understanding, and facilitating risk assessment.
Fusaro, A., Zecchin, B., Giussani, E., Palumbo, E., Agüero-García, M., Bachofen, C., Bálint, Á., et al. 2024. High pathogenic avian influenza A(H5) viruses of clade 2.3.4.4b in Europe – why trends of virus evolution are more difficult to predict. Virus Evolution, veae027. [reference]
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Miller, L.N., Saadawi, W.K., Hamouda, W.B., Elgari, A.S., Abdulkarim, E.A., Lmrabet, A.M.M., Elbukhmari, A.E., et al. 2024. Assessing One Health capacities for transboundary zoonotic diseases at the Libya-Tunisia border. One Health Outlook, 6(1):3. [reference]
Si, Y., Skidmore, A. K., Wang, T., de Boer, W. F., Debba, P., Toxopeus, A. G., Li, L., & Prins, H. H. 2009. Spatio-temporal dynamics of global H5N1 outbreaks match bird migration patterns. Geospatial Health, 4(1):65–78. [reference]
Olawuyi, K., Orole, O., Meseko, C., Monne, I., Shittu, I., Bianca, Z., Fusaro, A., et al. 2024. The Public Health Importance and Management of Infectious Poultry Diseases in Smallholder Systems in Africa. Influenza Other Respir Viruses, 18(2):e13254. [reference]
Monjane, I. V. A., Djedje, H., Tamele, E., Nhabomba, V., Tivane, A. R., Massicame, Z. E., Arone, D. M., Pastori, A., Bortolami, A., Monne, I., Woma, T., Lamien, C. E. & Dundon, W. G. 2024. H7N6 highly pathogenic avian influenza in Mozambique, 2023. Emerging Microbes & Infections, 13, (1). [reference]
Sanogo, I.N., Guinat, C., Dellicour, S., Diakité, M.A., Niang, M., Koita, O.A., Camus, C. & Ducatez, M. 2024. Genetic insights of H9N2 avian influenza viruses circulating in Mali and phylogeographic patterns in Northern and Western Africa. Virus Evolution, 10(1):veae011. [reference]
Glazunova, A., Krasnova, E., Bespalova, T., Sevskikh, T., Lunina, D., Titov, I., Sindryakova, I. & Blokhin, A. 2024. A highly pathogenic avian influenza virus H5N1 clade 2.3.4.4 detected in Samara Oblast, Russian Federation. Front Vet Sci, 11 – 2024. [reference]
Grace, D., Knight-Jones, T. J., Melaku, A., Alders, R. & Jemberu, W. T. 2024. The Public Health Importance and Management of Infectious Poultry Diseases in Smallholder Systems in Africa. Foods, 13(3), 411. [reference]
Kenmoe, S., Takuissu, G.R., Ebogo-Belobo, J.T., Kengne-Ndé, C., Mbaga, D.S., Bowo-Ngandji, A. & Ondigui Ndzie, J.L. et al. 2024. A systematic review of influenza virus in water environments across human, poultry, and wild bird habitats. Water Res X, 22:100210. [reference]
Roberts, L.C., Abernethy, D., Roberts, D.G., Ludynia, K., O'Kennedy, M.M., Abolnik, C. 2023. Vaccination of African penguins (Spheniscus demersus) against high-pathogenicity avian influenza.Vet Rec, e3616. [reference]
Abolnik, C. 2023. Spillover of an endemic avian Influenza H6N2 chicken lineage to ostriches and reassortment with clade 2.3.4.4b H5N1 high pathogenicity viruses in chickens. Vet Res Commun. [reference]
Fagrach, A., Arbani, O., Karroute, O., El-Ftouhy, F.Z., Kichou, F., Bouslikhane, M., Fellahi, S. 2023. Prevalence of major infectious diseases in backyard chickens from rural markets in Morocco. Vet World, 16(9):1897-1906. [reference]
Meseko, C., Ameji, N.O., Kumar, B. & Culhane, M. 2023. Rational approach to vaccination against highly pathogenic avian influenza in Nigeria: a scientific perspective and global best practice. Arch Virol, 168(10):263. [reference]
Agha, A.S.K., Benlashehr, I., Naffati, K.M., Bshina, S.A. & Khashkhosha, A.A. 2023. Correlation of avian influenzaH9N2 with high mortality in broiler flocks in the southwest of Tripoli, Libya. Open Vet J, 13(6):715-722. [reference].
Bongono, E.F., Kaba, L., Camara, A., Touré, A., Ngoma, M.P., Yanogo, P.K., Kanyala, E. & SOW A. 2023. Évaluation de la biosécurité et facteurs associés à l'influenza aviaire dans les fermes avicoles de Coyah, Guinée, 2019-2020. Med Trop Sante Int. 2023 3(2):25. [reference].
Isibor, P.O., Onwaeze, O.O., Kayode-Edwards, I.I., Agbontaen, D.O., Ifebem-Ezima, A.M., Bilewu, O., Onuselogu, C., Akinniyi, A.P., Obafemi, Y.D. & Oniha, M.I. 2023. Investigating and combatting the key drivers of viral zoonoses in Africa: an analysis of eight epidemics. Braz J Biol, 84:e270857. [reference]
Lebarbenchon, C., Boucher, S., Feare, C., Dietrich, M., Larose, C., Humeau, L., Le Corre, M. & Jaeger, A. 2023. Migratory patterns of two major influenza virus host species on tropical islands. R Soc Open Sci, 10(10):230600. [reference]
Jbenyeni, A., Croville, G., Cazaban, C. & Guérin, J.L. 2023. Predominance of low pathogenic avian influenza virus H9N2 in the respiratory co-infections in broilers in Tunisia: a longitudinal field study, 2018-2020. Vet Res, 54(1):88. [reference]
Alhaji, N.B., Adeiza, A.M., Godwin, E.A., Haruna, A.E., Aliyu, M.B. & Odetokun, I.A. 2023. An assessment of the highly pathogenic avian influenza resurgence at human-poultry-environment interface in North-central Nigeria: Sociocultural determinants and One Health implications. One health, 16:100574 [reference]
Miller, LmNm, Elmselati, H., Fogarty, A.S., Farhat, M.E., Standley, C.J., Abuabaid, H.M. & Zorgani, A. 2023. Using One Health assessments to leverage endemic disease frameworks for emerging zoonotic disease threats in Libya. PLOS Glob Public Health, 3(7):e0002005 [reference]
Abolnik, C., Phiri, T., Peyrot, B., de Beer, R., Snyman, A., Roberts, D., Ludynia, K. et al. 2023. The Molecular Epidemiology of Clade 2.3.4.4B H5N1 High Pathogenicity Avian Influenza in Southern Africa, 2021–2022. Viruses, 15(6):1383. [reference]
Meseko, C., Milani, A., Inuwa, B., Chinyere, C., Shittu, I., Ahmed, J., Giussani, E. et al. 2023. The Evolution of Highly Pathogenic Avian Influenza A (H5) in Poultry in Nigeria, 2021–2022. Viruses,15:1387. [reference]
Nma Bida Alhaji, Abdulrahman Musa Adeiza, Enid Abutu Godwin, Aliyu Evuti Haruna, Mohammed Baba Aliyu and Ismail Ayoade Odetokun. 2023. An assessment of the highly pathogenic avian influenza resurgence at human-poultry-environment interface in North-central Nigeria: Sociocultural determinants and One Health implications. One Health, 16:100574. [reference]
Lo, F.T., Zecchin, B., Diallo, A.A., Racky, O., Tassoni, L., Diop, A., Diouf, M., Diouf, M., Samb, Y.N., Pastori, A., Gobbo, F., Ellero, F., Diop, M., Lo, M.M., Diouf, M.N., Fall, M., Ndiaye, A.A., Gaye, A.M., Badiane, M., Lo, M., Youm, B.N., Ndao, I., Niaga, M., Terregino, C., Diop, B., Ndiaye, Y., Angot, A., Seck, I., Niang, M., Soumare, B., Fusaro, A. & Monne, I. 2022. Intercontinental Spread of Eurasian Highly Pathogenic Avian Influenza A(H5N1) to Senegal. Emerg Infect Dis. 28(1):234-237. [reference]
Panzarin, V., Marciano, S., Fortin, A., Brian, I., D'Amico, V., Gobbo, F., Bonfante, F., Palumbo, E., Sakoda, Y., Le, K.T., Chum D.H., Shittu, I., Meseko, C., Haido, A.M., Odoom, T., Diouf, M.N., Djegui, F., Steensels, M., Terregino, C. & Monne, I. 2022. Redesign and Validation of a Real-Time RT-PCR to Improve Surveillance for Avian Influenza Viruses of the H9 Subtype. Viruses. 14(6):1263. [reference]
Benin:
Burkina Faso:
Côte d’Ivoire:
Democratic Republic of the Congo:
Ethiopia:
Gambia:
Ghana:
Guinea:
Kenya:
Liberia:
Mali:
Niger:
Nigeria:
Senegal:
Sierra Leone:
Somalia:
Togo:
Uganda:
Zambia:
ECTAD ESA
ECTAD WCA
Burkina Faso:
Ethiopia:
Gabon:
Ghana:
Liberia
Mali:
Niger:
Nigeria:
Senegal:
Sierra Leone:
Information provided herein is current as of the date of issue. Information added or changed since the last Sub-Saharan HPAI situation update appears in orange. For poultry cases with unknown onset dates, reporting dates were used instead. FAO compiles information communicated by field officers on the ground in affected countries, from regional offices, and from the World Organisation for Animal Health [WOAH], as well as peer-reviewed scientific articles. FAO makes every effort to ensure, but does not guarantee, accuracy, completeness or authenticity of the information. The boundaries and names shown and the designations used on these map(s) do not imply the expression of any opinion whatsoever on the part of FAO concerning the legal status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers and boundaries. Dashed lines on maps represent approximate border lines for which there may not yet be full agreement.
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